An Environmentally Sensitive Zinc-selective Two-photon NIR Fluorescent Turn-on Probe and Zinc Sensing in Stroke

Overview

Journal J Pharm Anal

Specialty Chemistry

Date 2024 Apr 24

PMID 38655400

Authors

Junfeng Wang

Qibing Liu

Yingbo Li

Yi Pang

Affiliations

Soon will be listed here.

Abstract

A two-photon near infrared (NIR) fluorescence turn-on sensor with high selectivity and sensitivity for Zn detection has been developed. This sensor exhibits a large Stokes' shift (∼300 nm) and can be excited from 900 to 1000 nm, with an emission wavelength of ∼785 nm, making it ideal for imaging in biological tissues. The sensor's high selectivity for Zn over other structurally similar cations, such as Cd, makes it a promising tool for monitoring zinc ion levels in biological systems. Given the high concentration of zinc in thrombi, this sensor could provide a useful tool for thrombus imaging.

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