Methodological Advances Enabled by the Construction of a Synthetic Yeast Genome

Overview

Journal Cell Rep Methods

Specialty Cell Biology

Date 2024 Apr 23

PMID 38653205

Authors

Daniel Schindler

Roy S K Walker

Yizhi Cai

Affiliations

Soon will be listed here.

Abstract

The international Synthetic Yeast Project (Sc2.0) aims to construct the first synthetic designer eukaryote genome. Over the past few years, the Sc2.0 consortium has achieved several significant milestones by synthesizing and characterizing all 16 nuclear chromosomes of the yeast Saccharomyces cerevisiae, as well as a 17de novo neochromosome containing all nuclear tRNA genes. In this commentary, we discuss the recent technological advances achieved in this project and provide a perspective on how they will impact the emerging field of synthetic genomics in the future.

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