Research Progress on the Improvement of Cardiovascular Diseases Through the Autonomic Nervous System Regulation of the NLRP3 Inflammasome Pathway

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2024 Apr 23

PMID 38650918

Authors

Yuchi Hu

Songyuan Dai

Lulu Zhao

Ling Zhao

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease stands as a leading global cause of mortality. Nucleotide-binding Oligomerization Domain-like Receptor Protein 3 (NLRP3) inflammasome is widely acknowledged as pivotal factor in specific cardiovascular disease progression, such as myocardial infarction, heart failure. Recent investigations underscore a close interconnection between autonomic nervous system (ANS) dysfunction and cardiac inflammation. It has been substantiated that sympathetic nervous system activation and vagus nerve stimulation (VNS) assumes critical roles withinNLRP3 inflammasome pathway regulation, thereby contributing to the amelioration of cardiac injury and enhancement of prognosis in heart diseases. This article reviews the nexus between NLRP3 inflammasome and cardiovascular disorders, elucidating the modulatory functions of the sympathetic and vagus nerves within the ANS with regard to NLRP3 inflammasome. Furthermore, it delves into the potential therapeutic utility of NLRP3 inflammasome to be targeted by VNS. This review serves as a valuable reference for further exploration into the potential mechanisms underlying VNS in the modulation of NLRP3 inflammasome.

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References

Xiao H, Li H, Wang J, Zhang J, Shen J, An X . IL-18 cleavage triggers cardiac inflammation and fibrosis upon β-adrenergic insult. Eur Heart J. 2017; 39(1):60-69. DOI: 10.1093/eurheartj/ehx261. View

Banke A, Fosbol E, Ewertz M, Videbaek L, Dahl J, Poulsen M . Long-Term Risk of Heart Failure in Breast Cancer Patients After Adjuvant Chemotherapy With or Without Trastuzumab. JACC Heart Fail. 2019; 7(3):217-224. DOI: 10.1016/j.jchf.2018.09.001. View

Darwesh A, Keshavarz-Bahaghighat H, Jamieson K, Seubert J . Genetic Deletion or Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Cardiac Ischemia/Reperfusion Injury by Attenuating NLRP3 Inflammasome Activation. Int J Mol Sci. 2019; 20(14). PMC: 6678157. DOI: 10.3390/ijms20143502. View

Zhou W, Chen C, Chen Z, Liu L, Jiang J, Wu Z . NLRP3: A Novel Mediator in Cardiovascular Disease. J Immunol Res. 2018; 2018:5702103. PMC: 5911339. DOI: 10.1155/2018/5702103. View

Sabbah H, Ilsar I, Zaretsky A, Rastogi S, Wang M, Gupta R . Vagus nerve stimulation in experimental heart failure. Heart Fail Rev. 2010; 16(2):171-8. PMC: 3784341. DOI: 10.1007/s10741-010-9209-z. View

Amin J, Boche D, Rakic S . What do we know about the inflammasome in humans?. Brain Pathol. 2016; 27(2):192-204. PMC: 8029064. DOI: 10.1111/bpa.12479. View

Lyon A . Heart failure resulting from cancer treatment: still serious but an opportunity for prevention. Heart. 2018; 105(1):6-8. DOI: 10.1136/heartjnl-2018-313493. View

Wang H, Jing Z . Inflammation and cardiovascular diseases. Chronic Dis Transl Med. 2020; 6(4):215-218. PMC: 7729114. DOI: 10.1016/j.cdtm.2020.09.003. View

Li D, Liu J, Liu B, Hu H, Sun L, Miao Y . Acetylcholine inhibits hypoxia-induced tumor necrosis factor-α production via regulation of MAPKs phosphorylation in cardiomyocytes. J Cell Physiol. 2010; 226(4):1052-9. DOI: 10.1002/jcp.22424. View

10.

Ahmed M, Nudy M, Bussa R, Weigel F, Naccarelli G, Maheshwari A . Non-pharmacologic autonomic neuromodulation for treatment of heart failure: A systematic review and meta-analysis of randomized controlled trials. Trends Cardiovasc Med. 2022; 34(2):101-107. DOI: 10.1016/j.tcm.2022.09.007. View

11.

Lu B, Kwan K, Levine Y, Olofsson P, Yang H, Li J . α7 nicotinic acetylcholine receptor signaling inhibits inflammasome activation by preventing mitochondrial DNA release. Mol Med. 2014; 20:350-8. PMC: 4153835. DOI: 10.2119/molmed.2013.00117. View

12.

Diaz-Del-Olmo I, Worboys J, Martin-Sanchez F, Gritsenko A, Ambrose A, Tannahill G . Internalization of the Membrane Attack Complex Triggers NLRP3 Inflammasome Activation and IL-1β Secretion in Human Macrophages. Front Immunol. 2021; 12:720655. PMC: 8506164. DOI: 10.3389/fimmu.2021.720655. View

13.

Xue R, Sun L, Yu X, Li D, Zang W . Vagal nerve stimulation improves mitochondrial dynamics via an M receptor/CaMKKβ/AMPK pathway in isoproterenol-induced myocardial ischaemia. J Cell Mol Med. 2016; 21(1):58-71. PMC: 5192749. DOI: 10.1111/jcmm.12938. View

14.

Shao W, Yeretssian G, Doiron K, Hussain S, Saleh M . The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock. J Biol Chem. 2007; 282(50):36321-9. DOI: 10.1074/jbc.M708182200. View

15.

Hamann J, Ruble S, Stolen C, Wang M, Gupta R, Rastogi S . Vagus nerve stimulation improves left ventricular function in a canine model of chronic heart failure. Eur J Heart Fail. 2013; 15(12):1319-26. PMC: 3895958. DOI: 10.1093/eurjhf/hft118. View

16.

Sun Y, Chao S, Ouyang H, Zhang W, Luo W, Nie Q . Hybrid nanogenerator based closed-loop self-powered low-level vagus nerve stimulation system for atrial fibrillation treatment. Sci Bull (Beijing). 2022; 67(12):1284-1294. DOI: 10.1016/j.scib.2022.04.002. View

17.

Shrivastava G, Visoso-Carvajal G, Garcia-Cordero J, Leon-Juarez M, Chavez-Munguia B, Lopez T . Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome. Front Immunol. 2020; 11:352. PMC: 7076137. DOI: 10.3389/fimmu.2020.00352. View

18.

Yu J, Miyamoto S . Molecular Signaling to Preserve Mitochondrial Integrity against Ischemic Stress in the Heart: Rescue or Remove Mitochondria in Danger. Cells. 2021; 10(12). PMC: 8699551. DOI: 10.3390/cells10123330. View

19.

Golforoush P, Yellon D, Davidson S . Mouse models of atherosclerosis and their suitability for the study of myocardial infarction. Basic Res Cardiol. 2020; 115(6):73. PMC: 7704510. DOI: 10.1007/s00395-020-00829-5. View

20.

Xin J, Wu J, Hu G, Gu H, Feng Y, Wang S . α-AR overactivation induces cardiac inflammation through NLRP3 inflammasome activation. Acta Pharmacol Sin. 2019; 41(3):311-318. PMC: 7468364. DOI: 10.1038/s41401-019-0305-x. View