Molecular Epidemiology and Hematological Profiles of Hemoglobin Variants in Southern Thailand

Overview

Journal Sci Rep

Specialty Science

Date 2024 Apr 22

PMID 38649425

Authors

Wanicha Tepakhan

Sataron Kanjanaopas

Korntip Sreworadechpisal

Tipparat Penglong

Pornpun Sripornsawan

Chaowanee Wangchauy

Chadaporn Nokkong

Chulalak Kongkan

Saristha Buathong

Affiliations

Soon will be listed here.

Abstract

Data on hemoglobin (Hb) variants in southern Thailand are lacking. This study aimed to reassess the frequency of Hb variants and the clinical aspects of compound heterozygous Hb variant with other hemoglobinopathies. We enrolled 13,391 participants from ten provinces in southern Thailand during 2015-2022. Hb analysis was performed using capillary electrophoresis, and mutations in the HBA and HBB genes were identified using PCR or DNA sequencing. Hb variants were identified in 337 (2.5%) unrelated subjects. Nine β-chain variants, namely Hb Malay (76.9%), Hb C (10.1%), Hb D-Punjab (2.9%), Hb G-Makassar (2.3%), Hb Dhonburi (2.3%), Hb Tak (1.4%), Hb J-Bangkok (1.4%), Hb New York (0.3%), and Hb Hope (0.3%), and four α-chain variants-Hb G-Georgia (HBA1) (0.9%), Hb G-Georgia (HBA2) (0.3%), Hb Q-Thailand (0.6%), and Hb St. Luke's-Thailand (0.3%)-were identified. The southern population exhibited a distinct spectrum of Hb variants compared to that observed in the populations from other areas. Several compound heterozygous genotypes were also identified. Combining Hb Malay with Hb E or high Hb F determinants did not require a blood transfusion. This study provides essential information for genetic counseling in thalassemia prevention and control programs in this region.

Citing Articles

Novel Insights into Hb Shaare Zedek Associated with β-Thalassemia: Molecular Characteristics, Genetic Origin and Diagnostic Approaches.

Satthakarn S, Srisuwan W, Kunyanone N, Panyasai S Int J Mol Sci. 2024; 25(16).

PMID: 39201263 PMC: 11354257. DOI: 10.3390/ijms25168578.

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