The Nucleoid Protein HU Positively Regulates the Expression of Type VI Secretion Systems in

Overview

Journal mSphere

Publisher American Society for Microbiology

Specialties Microbiology
Parasitology

Date 2024 Apr 22

PMID 38647313

Authors

Gabriela Hernandez-Martinez

Miguel A Ares

Roberto Rosales-Reyes

Jorge Soria-Bustos

Jorge Antonio Yanez-Santos

Maria L Cedillo

Jorge A Giron

Ygnacio Martinez-Laguna

Fenfei Leng

J Antonio Ibarra

Miguel A De la Cruz

Affiliations

Soon will be listed here.

Abstract

Importance: T6SS is a nanomachine that functions as a weapon of bacterial destruction crucial for successful colonization in a specific niche. expresses two T6SSs required for bacterial competition, adherence, biofilm formation, and intestinal colonization. Expression of T6SS genes in pathogenic bacteria is controlled by multiple regulatory systems, including two-component systems, global regulators, and nucleoid proteins. Here, we reported that the HU nucleoid protein directly activates both T6SSs in , affecting the T6SS-related phenotypes. Our data describe HU as a new regulator involved in the transcriptional regulation of T6SS and its impact on pathogenesis.

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