Allogeneic Platelet-rich Plasma for Knee Osteoarthritis in Patients with Primary Immune Thrombocytopenia: A Randomized Clinical Trial

Overview

Journal iScience

Publisher Cell Press

Date 2024 Apr 22

PMID 38646173

Authors

Xiaohang Zhu

Lingying Zhao

Nicoletta Riva

Ziqiang Yu

Miao Jiang

Feng Zhou

Alexander Gatt

Peter V Giannoudis

Jiong Jiong Guo

Affiliations

Soon will be listed here.

Abstract

The treatment of painful KOA in adult patients with ITP has not been well studied yet. We conducted a prospective, double-blind, randomized, placebo-controlled trial to evaluate the efficacy of intra-articular allogeneic PRP injections on symptoms and joint structure in patients with KOA and ITP. 80 participants were randomly allocated in a 1:1 ratio to allogeneic PRP group or saline group. The primary outcome was the WOMAC total score at 12 months post-injection. The number of patients in each group who achieved MCID of primary outcome showed a statistically significant difference only at 3-month (27/39 vs. 5/39, = 0.001) and 6-month (15/39 vs. 3/38, = 0.032). The difference in WOMAC total score exceeded the MCID only at 3 month (mean difference of -15.1 [95% CI -20.7 to -9.5], < 0.001). Results suggest that allogeneic PRP was superior to placebo only with respect to symptoms at 3-month of follow-up.

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