Association of Change in Cardiovascular Health Based on Life's Essential 8 with Incident Cardiovascular Disease

Overview

Journal Am J Prev Cardiol

Specialty Cardiology & Vascular Diseases

Date 2024 Apr 22

PMID 38646020

Authors

Chao Song

Xunjie Cheng

Yongping Bai

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate whether and to what extent changes in cardiovascular health (CVH) based on life's essential 8 (LE8) are associated with incident cardiovascular disease (CVD).

Methods: A total of 7,194 participants were derived from UK Biobank. CVH was evaluated using a modified version of LE8. Participants were classified into three groups according to their LE8 score: high CVH (LE8 score≥80), moderate CVH (50≤LE8 score<80), and low CVH (LE8 score<50). Changes in CVH between 2006/2010 and 2012/2013 were analyzed.

Results: During a median of 10.3 years of follow-up, CVD was observed in 597 participants. Compared to the consistent moderate group, the moderate to low group was associated with about 128 % increased risk of CVD (Hazard ratio [HR]: 2.28; 95 % confidence interval [CI]: 1.61, 3.23), and the relevant HR (95 % CI) was 2.19 (1.46, 3.29) for the consistent low group; no statistically significant results were observed in the other groups. Moreover, no statistically significant exposure-response association between absolute change in LE8 score and incident CVD was documented (=0.15).

Conclusion: Change in CVH based on LE8 was associated with the risk of CVD; however, the relationship varied widely in different CVH change patterns.

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