[Alcohol Abstinence and Accelerated Biological Aging Among Middle-Aged and Older Adults: Evidence From the UK Biobank]

Overview

Journal Sichuan Da Xue Xue Bao Yi Xue Ban

Specialty General Medicine

Date 2024 Apr 22

PMID 38645852

Authors

Hongxiang Chen

Jiajie Cai

Jun Wei

Hongmei Zhang

Yi Xiang

Zitong Huang

Hao Xu

Xiong Xiao

Xing Zhao

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the longitudinal association between alcohol abstinence and accelerated biological aging among middle-aged and older adults and to explore the potential effect modifiers influencing the association.

Methods: Utilizing the clinico-biochemical and anthropometric data from the baseline and first repeat survey of the UK Biobank (UKB), we employed the Klemera and Doubal method (KDM) to construct the biological age (BA) and calculate BA acceleration. Change analysis based on multivariate linear regression models was employed to explore the association between changes in alcohol abstinence and changes in BA acceleration. Age, sex, smoking status, tea and coffee consumption, and body mass index were considered as the stratification factors for conducting stratified analysis.

Results: A total of 5 412 participants were included. Short-term alcohol abstinence (=1.00, 95% confidence interval []: 0.15-1.86) was found to accelerate biological aging when compared to consistent never drinking, while long-term abstinence (=-0.20, 95% : -1.12-0.71) did not result in a significant acceleration of biological aging. Body mass index may be a potential effect modifier.

Conclusion: Short-term alcohol abstinence was associated with accelerated biological aging, but the effect gradually diminishes over extended periods of abstinence.

References

Klemera P, Doubal S . A new approach to the concept and computation of biological age. Mech Ageing Dev. 2005; 127(3):240-8. DOI: 10.1016/j.mad.2005.10.004. View

Zhang X, Gao X, Lyu Y, Zhou J, Wei Y, Yin Z . Alcohol Cessation in Late Life is Associated with Lower Risk of Cognitive Impairment among the Older Adults in China. Biomed Environ Sci. 2021; 34(7):509-519. DOI: 10.3967/bes2021.071. View

Ollier W, Sprosen T, Peakman T . UK Biobank: from concept to reality. Pharmacogenomics. 2005; 6(6):639-46. DOI: 10.2217/14622416.6.6.639. View

Song J . Amygdala activity and amygdala-hippocampus connectivity: Metabolic diseases, dementia, and neuropsychiatric issues. Biomed Pharmacother. 2023; 162:114647. DOI: 10.1016/j.biopha.2023.114647. View

Mewton L, Visontay R, Hoy N, Lipnicki D, Sunderland M, Lipton R . The relationship between alcohol use and dementia in adults aged more than 60 years: a combined analysis of prospective, individual-participant data from 15 international studies. Addiction. 2022; 118(3):412-424. PMC: 9898084. DOI: 10.1111/add.16035. View

John U, Rumpf H, Hanke M, Meyer C . Alcohol abstinence and mortality in a general population sample of adults in Germany: A cohort study. PLoS Med. 2021; 18(11):e1003819. PMC: 8562854. DOI: 10.1371/journal.pmed.1003819. View

Thompson B, Maleki N, Kelly J, Sy K, Oscar-Berman M . Brain, behavioral, affective, and sex correlates of recovery from alcohol use disorders. Alcohol Clin Exp Res. 2021; 45(8):1578-1595. PMC: 8429096. DOI: 10.1111/acer.14658. View

Zindler T, Frieling H, Fliedner L, Veer I, Neyazi A, Awasthi S . How alcohol makes the epigenetic clock tick faster and the clock reversing effect of abstinence. Addict Biol. 2022; 27(5):e13198. DOI: 10.1111/adb.13198. View

Levine M . Modeling the rate of senescence: can estimated biological age predict mortality more accurately than chronological age?. J Gerontol A Biol Sci Med Sci. 2012; 68(6):667-74. PMC: 3660119. DOI: 10.1093/gerona/gls233. View

10.

Fuchs F, Costa Fuchs S . The Effect of Alcohol on Blood Pressure and Hypertension. Curr Hypertens Rep. 2021; 23(10):42. DOI: 10.1007/s11906-021-01160-7. View

11.

White I, Royston P, Wood A . Multiple imputation using chained equations: Issues and guidance for practice. Stat Med. 2011; 30(4):377-99. DOI: 10.1002/sim.4067. View

12.

Viola T, Orso R, Florian L, Garcia M, Gomes M, Mardini E . Effects of substance use disorder on oxidative and antioxidative stress markers: A systematic review and meta-analysis. Addict Biol. 2022; 28(1):e13254. PMC: 10078266. DOI: 10.1111/adb.13254. View

13.

Roberto M, Kirson D, Khom S . The Role of the Central Amygdala in Alcohol Dependence. Cold Spring Harb Perspect Med. 2020; 11(2). PMC: 7382982. DOI: 10.1101/cshperspect.a039339. View

14.

Xiang Y, Xu H, Chen H, Tang D, Huang Z, Zhang Y . Tea consumption and attenuation of biological aging: a longitudinal analysis from two cohort studies. Lancet Reg Health West Pac. 2023; 42:100955. PMC: 10700389. DOI: 10.1016/j.lanwpc.2023.100955. View

15.

Pullen Jr R . Alcohol withdrawal syndrome. Nursing. 2023; 53(7):20-27. DOI: 10.1097/01.NURSE.0000936760.82108.69. View

16.

Voskoboinik A, Kalman J, De Silva A, Nicholls T, Costello B, Nanayakkara S . Alcohol Abstinence in Drinkers with Atrial Fibrillation. N Engl J Med. 2020; 382(1):20-28. DOI: 10.1056/NEJMoa1817591. View

17.

VanderWeele T, Ding P . Sensitivity Analysis in Observational Research: Introducing the E-Value. Ann Intern Med. 2017; 167(4):268-274. DOI: 10.7326/M16-2607. View

18.

Yao X, Ni M, Cheung F, Wu J, Schooling C, Leung G . Change in moderate alcohol consumption and quality of life: evidence from 2 population-based cohorts. CMAJ. 2019; 191(27):E753-E760. PMC: 6739059. DOI: 10.1503/cmaj.181583. View

19.

Smith J, Hou T, Hu F, Rimm E, Spiegelman D, Willett W . A Comparison of Different Methods for Evaluating Diet, Physical Activity, and Long-Term Weight Gain in 3 Prospective Cohort Studies. J Nutr. 2015; 145(11):2527-34. PMC: 4620721. DOI: 10.3945/jn.115.214171. View

20.

Sullivan E, Pfefferbaum A . Alcohol use disorder: Neuroimaging evidence for accelerated aging of brain morphology and hypothesized contribution to age-related dementia. Alcohol. 2022; 107:44-55. PMC: 11424507. DOI: 10.1016/j.alcohol.2022.06.002. View