Effects of Combined Cognitive and Resistance Training on Physical and Cognitive Performance and Psychosocial Well-being of Older Adults ≥65: Study Protocol for a Randomised Controlled Trial

Overview

Journal BMJ Open

Specialty General Medicine

Date 2024 Apr 20

PMID 38643006

Authors

Deniz Aminirakan

Bjorn Losekamm

Bettina Wollesen

Affiliations

Soon will be listed here.

Abstract

Introduction: With increasing life expectancy of older adult population, maintaining independence and well-being in later years is of paramount importance. This study aims to investigate the impact of three distinct interventions: cognitive training, resistance training and a combination of both, compared with an inactive control group, on cognitive performance, mobility and quality of life in adults aged ≥65 years.

Methods And Analysis: This trial will investigate healthy older adults aged ≥65 years living independently without cognitive impairments. Participants will be randomly assigned to one of four groups: (1) cognitive training, (2) resistance training, (3) combined cognitive and resistance training, and (4) control group (n=136 participants with 34 participants per group). The interventions will be conducted over 12 weeks. The cognitive training group will receive group-based activities for 45-60 min two times a week. The resistance training group exercises will target six muscle groups and the combined group will integrate cognitive tasks into the resistance training sessions. Primary outcomes are: Short Physical Performance Battery, Sit-to-Stand Test, Montreal Cognitive Assessment, Trail Making Test and Stroop Test combined with gait on a treadmill (dual task). Life satisfaction will be measured by the Satisfaction With Life Scale. Secondary outcomes encompass hand grip strength and the Functional Independence Measure.

Ethics And Dissemination: Ethical approval was provided by the local Ethics Committee at the University of Hamburg (no. 2023_009). Informed consent will be obtained from all study participants. The results of the study will be distributed for review and discussion in academic journals and conferences.

Trial Registration Number: DRKS00032587.

References

Rosano C, Simonsick E, Harris T, Kritchevsky S, Brach J, Visser M . Association between physical and cognitive function in healthy elderly: the health, aging and body composition study. Neuroepidemiology. 2004; 24(1-2):8-14. DOI: 10.1159/000081043. View

Nakano M, Otonari T, Takara K, Carmo C, Tanaka C . Physical performance, balance, mobility, and muscle strength decline at different rates in elderly people. J Phys Ther Sci. 2014; 26(4):583-6. PMC: 3996426. DOI: 10.1589/jpts.26.583. View

Fitzpatrick A, Buchanan C, Nahin R, DeKosky S, Atkinson H, Carlson M . Associations of gait speed and other measures of physical function with cognition in a healthy cohort of elderly persons. J Gerontol A Biol Sci Med Sci. 2007; 62(11):1244-51. DOI: 10.1093/gerona/62.11.1244. View

Kelly M, Loughrey D, Lawlor B, Robertson I, Walsh C, Brennan S . The impact of cognitive training and mental stimulation on cognitive and everyday functioning of healthy older adults: a systematic review and meta-analysis. Ageing Res Rev. 2014; 15:28-43. DOI: 10.1016/j.arr.2014.02.004. View

Wollesen B, Wildbredt A, van Schooten K, Lim M, Delbaere K . The effects of cognitive-motor training interventions on executive functions in older people: a systematic review and meta-analysis. Eur Rev Aging Phys Act. 2020; 17:9. PMC: 7333372. DOI: 10.1186/s11556-020-00240-y. View

Lavin K, Roberts B, Fry C, Moro T, Rasmussen B, Bamman M . The Importance of Resistance Exercise Training to Combat Neuromuscular Aging. Physiology (Bethesda). 2019; 34(2):112-122. PMC: 6586834. DOI: 10.1152/physiol.00044.2018. View

Distefano G, Goodpaster B . Effects of Exercise and Aging on Skeletal Muscle. Cold Spring Harb Perspect Med. 2017; 8(3). PMC: 5830901. DOI: 10.1101/cshperspect.a029785. View

Koster A, Ding J, Stenholm S, Caserotti P, Houston D, Nicklas B . Does the amount of fat mass predict age-related loss of lean mass, muscle strength, and muscle quality in older adults?. J Gerontol A Biol Sci Med Sci. 2011; 66(8):888-95. PMC: 3184893. DOI: 10.1093/gerona/glr070. View

John A, Patel U, Rusted J, Richards M, Gaysina D . Affective problems and decline in cognitive state in older adults: a systematic review and meta-analysis. Psychol Med. 2018; 49(3):353-365. PMC: 6331688. DOI: 10.1017/S0033291718001137. View

10.

Tung J, Rose R, Gammada E, Lam I, Roy E, Black S . Measuring life space in older adults with mild-to-moderate Alzheimer's disease using mobile phone GPS. Gerontology. 2013; 60(2):154-62. DOI: 10.1159/000355669. View

11.

Hughes D, Ellefsen S, Baar K . Adaptations to Endurance and Strength Training. Cold Spring Harb Perspect Med. 2017; 8(6). PMC: 5983157. DOI: 10.1101/cshperspect.a029769. View

12.

Yogev-Seligmann G, Hausdorff J, Giladi N . The role of executive function and attention in gait. Mov Disord. 2007; 23(3):329-42. PMC: 2535903. DOI: 10.1002/mds.21720. View

13.

Eggenberger P, Schumacher V, Angst M, Theill N, de Bruin E . Does multicomponent physical exercise with simultaneous cognitive training boost cognitive performance in older adults? A 6-month randomized controlled trial with a 1-year follow-up. Clin Interv Aging. 2015; 10:1335-49. PMC: 4544626. DOI: 10.2147/CIA.S87732. View

14.

Angevaren M, Aufdemkampe G, Verhaar H, Aleman A, Vanhees L . Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev. 2008; (3):CD005381. DOI: 10.1002/14651858.CD005381.pub3. View

15.

Ali N, Tian H, Thabane L, Ma J, Wu H, Zhong Q . The Effects of Dual-Task Training on Cognitive and Physical Functions in Older Adults with Cognitive Impairment; A Systematic Review and Meta-Analysis. J Prev Alzheimers Dis. 2022; 9(2):359-370. DOI: 10.14283/jpad.2022.16. View

16.

Kent-Braun J, Callahan D, Fay J, Foulis S, Buonaccorsi J . Muscle weakness, fatigue, and torque variability: effects of age and mobility status. Muscle Nerve. 2013; 49(2):209-17. PMC: 3796051. DOI: 10.1002/mus.23903. View

17.

Lau L, Tou N, Jabbar K, Tang J, Gao J, Ding Y . Effects of Exercise Interventions on Physical Performance and Activities of Daily Living in Oldest-Old and Frail Older Adults: A Review of the Literature. Am J Phys Med Rehabil. 2023; 102(10):939-949. DOI: 10.1097/PHM.0000000000002246. View

18.

Gomez J, Curcio C, Alvarado B, Zunzunegui M, Guralnik J . Validity and reliability of the Short Physical Performance Battery (SPPB): a pilot study on mobility in the Colombian Andes. Colomb Med (Cali). 2014; 44(3):165-71. PMC: 4002038. View

19.

Domenech-Cebrian P, Martinez-Martinez M, Cauli O . Relationship between mobility and cognitive impairment in patients with Alzheimer's disease. Clin Neurol Neurosurg. 2019; 179:23-29. DOI: 10.1016/j.clineuro.2019.02.015. View

20.

Hicks G, Shardell M, Alley D, Miller R, Bandinelli S, Guralnik J . Absolute strength and loss of strength as predictors of mobility decline in older adults: the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2011; 67(1):66-73. PMC: 3260485. DOI: 10.1093/gerona/glr055. View