Evolution and Antigenic Differentiation of Avian Influenza A(H7N9) Virus, China

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2024 Apr 19

PMID 38640498

Authors

Yang Liu

Yuhua Chen

Zhiyi Yang

Yaozhong Lin

Siyuan Fu

Junhong Chen

Lingyu Xu

Tengfei Liu

Beibei Niu

Qiuhong Huang

Haixia Liu

Chaofeng Zheng

Ming Liao

Weixin Jia

Affiliations

Soon will be listed here.

Abstract

We characterized the evolution and molecular characteristics of avian influenza A(H7N9) viruses isolated in China during 2021-2023. We systematically analyzed the 10-year evolution of the hemagglutinin gene to determine the evolutionary branch. Our results showed recent antigenic drift, providing crucial clues for updating the H7N9 vaccine and disease prevention and control.

References

Jiang W, Hou G, Li J, Peng C, Wang S, Liu S . Antigenic Variant of Highly Pathogenic Avian Influenza A(H7N9) Virus, China, 2019. Emerg Infect Dis. 2019; 26(2). PMC: 6986829. DOI: 10.3201/eid2602.191105. View

Chen J, Liu Z, Li K, Li X, Xu L, Zhang M . Emergence of novel avian origin H7N9 viruses after introduction of H7-Re3 and rLN79 vaccine strains to China. Transbound Emerg Dis. 2021; 69(2):213-220. DOI: 10.1111/tbed.14401. View

Wang X, Jiang H, Wu P, Uyeki T, Feng L, Lai S . Epidemiology of avian influenza A H7N9 virus in human beings across five epidemics in mainland China, 2013-17: an epidemiological study of laboratory-confirmed case series. Lancet Infect Dis. 2017; 17(8):822-832. PMC: 5988584. DOI: 10.1016/S1473-3099(17)30323-7. View

Gu J, Yan Y, Zeng Z, Wang W, Gao R, Hu J . Characterization of two chicken origin highly pathogenic H7N9 viruses isolated in northern China. Vet Microbiol. 2022; 268:109394. DOI: 10.1016/j.vetmic.2022.109394. View

Wu Y, Hu J, Jin X, Li X, Wang J, Zhang M . Accelerated Evolution of H7N9 Subtype Influenza Virus under Vaccination Pressure. Virol Sin. 2021; 36(5):1124-1132. PMC: 8112217. DOI: 10.1007/s12250-021-00383-x. View

Zhang J, Ye H, Li H, Ma K, Qiu W, Chen Y . Evolution and Antigenic Drift of Influenza A (H7N9) Viruses, China, 2017-2019. Emerg Infect Dis. 2020; 26(8):1906-1911. PMC: 7392412. DOI: 10.3201/eid2608.200244. View

Yin X, Deng G, Zeng X, Cui P, Hou Y, Liu Y . Genetic and biological properties of H7N9 avian influenza viruses detected after application of the H7N9 poultry vaccine in China. PLoS Pathog. 2021; 17(4):e1009561. PMC: 8104392. DOI: 10.1371/journal.ppat.1009561. View

Zhang F, Bi Y, Wang J, Wong G, Shi W, Hu F . Human infections with recently-emerging highly pathogenic H7N9 avian influenza virus in China. J Infect. 2017; 75(1):71-75. DOI: 10.1016/j.jinf.2017.04.001. View

Ke C, Mok C, Zhu W, Zhou H, He J, Guan W . Human Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China. Emerg Infect Dis. 2017; 23(8):1332-1340. PMC: 5547808. DOI: 10.3201/eid2308.170600. View

10.

Wu J, Ke C, Lau E, Song Y, Cheng K, Zou L . Influenza H5/H7 Virus Vaccination in Poultry and Reduction of Zoonotic Infections, Guangdong Province, China, 2017-18. Emerg Infect Dis. 2018; 25(1):116-118. PMC: 6302570. DOI: 10.3201/eid2501.181259. View

11.

Qi W, Jia W, Liu D, Li J, Bi Y, Xie S . Emergence and Adaptation of a Novel Highly Pathogenic H7N9 Influenza Virus in Birds and Humans from a 2013 Human-Infecting Low-Pathogenic Ancestor. J Virol. 2017; 92(2). PMC: 5752946. DOI: 10.1128/JVI.00921-17. View

12.

Khare S, Gurry C, Freitas L, Schultz M, Bach G, Diallo A . GISAID's Role in Pandemic Response. China CDC Wkly. 2021; 3(49):1049-1051. PMC: 8668406. DOI: 10.46234/ccdcw2021.255. View

13.

Senne D, Panigrahy B, Kawaoka Y, Pearson J, Suss J, Lipkind M . Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential. Avian Dis. 1996; 40(2):425-37. View

14.

Yang L, Zhu W, Li X, Chen M, Wu J, Yu P . Genesis and Spread of Newly Emerged Highly Pathogenic H7N9 Avian Viruses in Mainland China. J Virol. 2017; 91(23). PMC: 5686710. DOI: 10.1128/JVI.01277-17. View

15.

Byrne A, Reid S, Seekings A, Nunez A, Obeso Prieto A, Ridout S . H7N7 Avian Influenza Virus Mutation from Low to High Pathogenicity on a Layer Chicken Farm in the UK. Viruses. 2021; 13(2). PMC: 7914596. DOI: 10.3390/v13020259. View