Evaluation of Retinal and Choroidal Thickness Changes in Overweight and Obese Adults Without Ocular Symptoms by Swept-source Optical Coherence Tomography

Overview

Journal Int J Ophthalmol

Specialty Ophthalmology

Date 2024 Apr 19

PMID 38638269

Authors

Qing-Jian Li

Sheng-Mei Zhou

Ling-Yu Zhang

An-Ni Lin

Yang Zhang

Jing Jiang

Xin Che

Yi-Wen Qian

Yan Liu

Zhi-Liang Wang

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate the relationship of overweight and obesity with retinal and choroidal thickness in adults without ocular symptoms by swept-source optical coherence tomography (SS-OCT).

Methods: According to the body mass index (BMI) results, the adults enrolled in the cross-sectional study were divided into the normal group (18.50≤BMI<25.00 kg/m), the overweight group (25.00≤BMI<30.00 kg/m), and the obesity group (BMI≥30.00 kg/m). The one-way ANOVA and the Chi-square test were used for comparisons. Pearson's correlation analysis was used to evaluate the relationships between the measured variables.

Results: This research covered the left eyes of 3 groups of 434 age- and sex-matched subjects each: normal, overweight, and obesity. The mean BMI was 22.20±1.67, 26.82±1.38, and 32.21±2.35 kg/m in normal, overweight and obesity groups, respectively. The choroid was significantly thinner in both the overweight and obesity groups compared to the normal group (<0.05 for all), while the retinal thickness of the three groups did not differ significantly. Pearson's correlation analysis showed that BMI was significantly negatively correlated with choroidal thickness, but no significant correlation was observed between BMI and retinal thickness.

Conclusion: Choroidal thickness is decreased in people with overweight or obesity. Research on changes in choroidal thickness contributes to the understanding of the mechanisms of certain ocular disorders in overweight and obese adults.

Citing Articles

Comment on: Evaluation of retinal and choroidal thickness changes in overweight and obese adults without ocular symptoms by swept-source optical coherence tomography.

Alacamli G Int J Ophthalmol. 2024; 17(11):2151-2152.

PMID: 39559313 PMC: 11528282. DOI: 10.18240/ijo.2024.11.24.

References

Zhang Q, Tie L, Wu S, Lv P, Huang H, Wang W . Overweight, Obesity, and Risk of Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2016; 57(3):1276-83. DOI: 10.1167/iovs.15-18637. View

Nickla D, Wallman J . The multifunctional choroid. Prog Retin Eye Res. 2010; 29(2):144-68. PMC: 2913695. DOI: 10.1016/j.preteyeres.2009.12.002. View

Wei Y, Huang H, Zhang X, Yu H, Liu B, Diao Y . Identification of retinal thickness and blood flow in age-related macular degeneration with reticular pseudodrusen. Int J Ophthalmol. 2023; 16(8):1268-1273. PMC: 10398519. DOI: 10.18240/ijo.2023.08.12. View

Black R, Victora C, Walker S, Bhutta Z, Christian P, de Onis M . Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet. 2013; 382(9890):427-451. DOI: 10.1016/S0140-6736(13)60937-X. View

Tan K, Gupta P, Agarwal A, Chhablani J, Cheng C, Keane P . State of science: Choroidal thickness and systemic health. Surv Ophthalmol. 2016; 61(5):566-81. DOI: 10.1016/j.survophthal.2016.02.007. View

Li Q, Qian Y, Xu S, Zhang M, Liang X, Che X . Relationships of Rheumatoid Factor with Thickness of Retina and Choroid in Subjects without Ocular Symptoms Using Swept-Source Optical Coherence Tomography. J Immunol Res. 2021; 2021:5547533. PMC: 8016561. DOI: 10.1155/2021/5547533. View

Can M, Kaplan F, Uzel M, Kiziltoprak H, Ergun M, Koc M . The association of Helicobacter pylori with choroidal and retinal nerve fiber layer thickness. Int Ophthalmol. 2017; 38(5):1915-1922. DOI: 10.1007/s10792-017-0677-1. View

Lee C, Zhang X, Yuan N, Tang S, Chen L, Cheung C . Comparison of choroidal thickness measurements between spectral domain optical coherence tomography and swept source optical coherence tomography in children. Sci Rep. 2021; 11(1):13749. PMC: 8253773. DOI: 10.1038/s41598-021-92980-9. View

Nagasawa T, Mitamura Y, Katome T, Shinomiya K, Naito T, Nagasato D . Macular choroidal thickness and volume in healthy pediatric individuals measured by swept-source optical coherence tomography. Invest Ophthalmol Vis Sci. 2013; 54(10):7068-74. DOI: 10.1167/iovs.13-12350. View

10.

Barrachina M, Hermida-Nogueira L, Moran L, Casas V, Hicks S, Sueiro A . Phosphoproteomic Analysis of Platelets in Severe Obesity Uncovers Platelet Reactivity and Signaling Pathways Alterations. Arterioscler Thromb Vasc Biol. 2020; 41(1):478-490. DOI: 10.1161/ATVBAHA.120.314485. View

11.

Jiang W, Jiang N, Liu G, Lin J, Li C, Zhao G . Structural measurements and vessel density of spectral-domain optic coherence tomography in early, moderate, and severe primary angle-closure glaucoma. Int J Ophthalmol. 2023; 16(7):1100-1109. PMC: 10333245. DOI: 10.18240/ijo.2023.07.15. View

12.

Ferrari G, Alberico C, Marques A, Kovalskys I, Gomez G, Rigotti A . Perceived urban environment attributes and obesity indices in adults: an 8-Nation study from Latin America. Sci Rep. 2022; 12(1):19598. PMC: 9666441. DOI: 10.1038/s41598-022-24209-2. View

13.

Chooi Y, Ding C, Magkos F . The epidemiology of obesity. Metabolism. 2018; 92:6-10. DOI: 10.1016/j.metabol.2018.09.005. View

14.

Copete S, Flores-Moreno I, Montero J, Duker J, Ruiz-Moreno J . Direct comparison of spectral-domain and swept-source OCT in the measurement of choroidal thickness in normal eyes. Br J Ophthalmol. 2013; 98(3):334-8. DOI: 10.1136/bjophthalmol-2013-303904. View

15.

Bulus A, Can M, Baytaroglu A, Dereli Can G, Cakmak H, Andiran N . Choroidal Thickness in Childhood Obesity. Ophthalmic Surg Lasers Imaging Retina. 2017; 48(1):10-17. DOI: 10.3928/23258160-20161219-02. View

16.

Wong A, Chan C, Hui S . Relationship of gender, body mass index, and axial length with central retinal thickness using optical coherence tomography. Eye (Lond). 2004; 19(3):292-7. DOI: 10.1038/sj.eye.6701466. View

17.

Jeon J, Hwang Y, Lee J, Kong E, Moon J, Hong S . Intravital Imaging of Circulating Red Blood Cells in the Retinal Vasculature of Growing Mice. Transl Vis Sci Technol. 2021; 10(4):31. PMC: 8083064. DOI: 10.1167/tvst.10.4.31. View

18.

Adhi M, Liu J, Qavi A, Grulkowski I, Lu C, Mohler K . Choroidal analysis in healthy eyes using swept-source optical coherence tomography compared to spectral domain optical coherence tomography. Am J Ophthalmol. 2014; 157(6):1272-1281.e1. DOI: 10.1016/j.ajo.2014.02.034. View

19.

Fang D, Li Q, Yan K, Xu S, Jiang J, Che X . Retinal and Choroidal Thickness in relation to C-Reactive Protein on Swept-Source Optical Coherence Tomography. J Immunol Res. 2021; 2021:6628224. PMC: 7850851. DOI: 10.1155/2021/6628224. View

20.

Yumusak E, Ornek K, Durmaz S, Cifci A, Guler H, Bacanli Z . Choroidal thickness in obese women. BMC Ophthalmol. 2016; 16(1):48. PMC: 4855894. DOI: 10.1186/s12886-016-0227-z. View