Correlation Between Serum 1,25(OH)2D3, Serum Phosphorus, and Parathyroid Hormone and Parathyroid Function After Central Lymph Node Dissection in Patients with Papillary Thyroid Carcinoma

Overview

Journal Mol Biotechnol

Publisher Springer

Specialties Biotechnology
Molecular Biology

Date 2024 Apr 18

PMID 38637449

Authors

Hongmei Yu

Haiqiang Li

Weiwei Su

Zhiwei Xu

Mengqi Xu

Chen Hang

Xiuping Li

Affiliations

Soon will be listed here.

Abstract

This work was to demonstrate the relationship between serum 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), serum phosphorus (SP), and parathyroid hormone (PTH) and parathyroid function after central lymph node dissection (CLND) in patients with papillary thyroid carcinoma (PTC). 200 PTC patients after CLND were included, who were rolled into a control group (CG) (n = 89 cases without hypoparathyroidism) and an observation group (OG) (n = 111 cases with complicated hypoparathyroidism). The 1,25(OH)2D3, SP, and PTH levels were detected, and the diagnostic effect of these indicators was assessed. The serum PTH levels of patients in CG after surgery were normal relative to those before surgery, while the serum PTH of patients in OG was relatively lower. 1,25(OH)2D3 concentration of patients in OG was also inferior to CG, while the SP level was superior (P < 0.05). Hypoparathyroidism was positively correlated with serum PTH (r = 0.382) and 1,25(OH)2D3 (r = 0.321) and negatively correlated with SP (r = - 0.211). The area under the curve (AUC) (0.893), sensitivity (90.83%), and specificity (94.77%) of the joint diagnosis of 1,25(OH)2D3 + SP + PTH were greatly superior to those of the single diagnosis and the pairwise diagnosis with the three indicators (P < 0.05). Hypoparathyroidism in patients with PTC after CLND surgery was positively correlated with 1,25(OH)2D3 and PTH and negatively correlated with SP concentration. In addition, the combination diagnosis of 1,25(OH)2D3, PTH, and SP worked well.

References

Cauteruccio M, Perna A, Vitiello R, Oliva M, Pesare E, Ziranu A . A rare case of post-traumatic infected pilomatricoma of the finger of the hand diagnosed after performing radioiodine therapy. J Biol Regul Homeost Agents. 2020; 34(3 Suppl. 2). View

Kotanidou E, Giza S, Tsinopoulou V, Margaritis K, Papadopoulou A, Sakellari E . The Prognostic Significance of BRAF Gene Analysis in Children and Adolescents with Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis. Diagnostics (Basel). 2023; 13(6). PMC: 10047331. DOI: 10.3390/diagnostics13061187. View

Stergioula A, Pantelis E, Kormas T, Agrogiannis G . Case report: skeletal muscle metastasis from follicular thyroid carcinoma presenting as synovial sarcoma. Front Oncol. 2023; 13:994729. PMC: 9950734. DOI: 10.3389/fonc.2023.994729. View

Paspala A, Papakonstantinou D, Pikoulis E, Tomos P, Nastos C . Synchronous Sternal Metastasectomy and Total Thyroidectomy for Differentiated Thyroid Cancer: A Rare Case Report. Cureus. 2022; 14(11):e31294. PMC: 9733711. DOI: 10.7759/cureus.31294. View

Kaul P, Kaul P, Poonia D, Jakhetiya A, Arora V, Garg P . Risk Benefit Analysis of Routine Thymectomy for Differentiated Thyroid Cancers: A Systematic Review. Surg J (N Y). 2021; 7(4):e307-e313. PMC: 8674089. DOI: 10.1055/s-0041-1736669. View

Obongo Anga R, Abbaci M, Guerlain J, Breuskin I, Casiraghi O, Marhic A . Intraoperative Autofluorescence Imaging for Parathyroid Gland Identification during Total Laryngectomy with Thyroidectomy. Cancers (Basel). 2023; 15(3). PMC: 9913419. DOI: 10.3390/cancers15030875. View

Liu X, Wong C, Chan W, Au I, Tang E, Lang B . Survival after hemithyroidectomy versus total thyroidectomy in non-high-risk differentiated thyroid cancer: population-based analysis. BJS Open. 2022; 6(6). PMC: 9692192. DOI: 10.1093/bjsopen/zrac146. View

Goodman W, Ward D, Martin K, Drayer D, Moore C, Xu J . Activation of the Calcium Receptor by Calcimimetic Agents Is Preserved Despite Modest Attenuating Effects of Hyperphosphatemia. J Am Soc Nephrol. 2021; 33(1):201-212. PMC: 8763177. DOI: 10.1681/ASN.2021060825. View

Zou Y, Zhang N, Tang Y, Zhan Z, Yang M, Lu Y . Predictive markers for severe hypocalcemia in dialysis patients with secondary hyperparathyroidism after near-total parathyroidectomy. Ann Palliat Med. 2021; 10(10):10712-10719. DOI: 10.21037/apm-21-2509. View

10.

Garcia Pascual L, Garcia Gonzalez L, Lao Luque X, Palomino Meneses L, Viscasillas Pallas G . Evaluation of an early detection protocol, intensive treatment and control of post-surgical hypoparathyroidism in the first month after total thyroidectomy. Endocrinol Diabetes Nutr (Engl Ed). 2023; 70(3):202-211. DOI: 10.1016/j.endien.2023.03.012. View

11.

Song J, Li L, Xu Z, Li J, Sun S, Chen C . Long-Term Survival in Patients With Papillary Thyroid Cancer Who Did Not Undergo Prophylactic Central Lymph Node Dissection: A SEER-Based Study. World J Oncol. 2022; 13(3):136-144. PMC: 9239496. DOI: 10.14740/wjon1483. View

12.

Chen Y, Chen S, Lin X, Huang X, Yu X, Chen J . Clinical Analysis of Cervical Lymph Node Metastasis Risk Factors and the Feasibility of Prophylactic Central Lymph Node Dissection in Papillary Thyroid Carcinoma. Int J Endocrinol. 2021; 2021:6635686. PMC: 7868159. DOI: 10.1155/2021/6635686. View

13.

Lin H, Tang H, Davis F, Mousa S, Incerpi S, Luidens M . Nongenomic regulation by thyroid hormone of plasma membrane ion and small molecule pumps. Discov Med. 2012; 14(76):199-206. View

14.

Sciacchitano S, De Francesco G, Piane M, Savio C, De Vitis C, Petrucci S . Complete Pseudo-Anodontia in an Adult Woman with Pseudo-Hypoparathyroidism Type 1a: A New Additional Nonclassical Feature?. Diagnostics (Basel). 2022; 12(12). PMC: 9777483. DOI: 10.3390/diagnostics12122997. View

15.

Baud G, Jannin A, Marciniak C, Chevalier B, Do Cao C, Leteurtre E . Impact of Lymph Node Dissection on Postoperative Complications of Total Thyroidectomy in Patients with Thyroid Carcinoma. Cancers (Basel). 2022; 14(21). PMC: 9657404. DOI: 10.3390/cancers14215462. View

16.

Godlewska P, Benke M, Stachlewska-Nasfeter E, Galczynski J, Pula B, Dedecjus M . Risk factors of permanent hypoparathyroidism after total thyroidectomy and central neck dissection for papillary thyroid cancer: a prospective study. Endokrynol Pol. 2020; 71(2):126-133. DOI: 10.5603/EP.a2020.0006. View

17.

Dawale K, Agrawal A . Parathyroid Hormone Secretion and Related Syndromes. Cureus. 2022; 14(10):e30251. PMC: 9650928. DOI: 10.7759/cureus.30251. View

18.

Zhukov A, Povaliaeva A, Abilov Z, Kovaleva E, Usoltseva L, Eremkina A . Parameters of Vitamin D Metabolism in Patients with Hypoparathyroidism. Metabolites. 2022; 12(12). PMC: 9782652. DOI: 10.3390/metabo12121279. View

19.

Xiang Z, Wang M, Miao C, Jin D, Wang H . Mechanism of calcitriol regulating parathyroid cells in secondary hyperparathyroidism. Front Pharmacol. 2022; 13:1020858. PMC: 9577402. DOI: 10.3389/fphar.2022.1020858. View

20.

Chindris A, Desai K, Ozgursoy S, Heckman M, Casler J . A Parathyroid Hormone-Guided Calcium and Calcitriol Supplementation Protocol Reduces Hypocalcemia-Related Readmissions Following Total Thyroidectomy. Endocr Pract. 2023; 29(4):260-265. DOI: 10.1016/j.eprac.2023.01.009. View