Mitochondrial Calcium Signaling in Non-neuronal Cells: Implications for Alzheimer's Disease Pathogenesis

Overview

Journal Biochim Biophys Acta Mol Basis Dis

Publisher Elsevier

Specialties Biochemistry
Biophysics
Genetics
Molecular Biology

Date 2024 Apr 17

PMID 38631408

Authors

Darpan Raghav

Shatakshi Shukla

Pooja Jadiya

Affiliations

Soon will be listed here.

Abstract

Mitochondrial dysregulation is pivotal in Alzheimer's disease (AD) pathogenesis. Calcium governs vital mitochondrial processes impacting energy conversion, oxidative stress, and cell death signaling. Disruptions in mitochondrial calcium (Ca) handling induce calcium overload and trigger the opening of mitochondrial permeability transition pore, ensuing energy deprivation and resulting in AD-related neuronal cell death. However, the role of Ca in non-neuronal cells (microglia, astrocytes, oligodendrocytes, endothelial cells, and pericytes) remains elusive. This review provides a comprehensive exploration of mitochondrial heterogeneity and calcium signaling, offering insights into specific differences among various brain cell types in AD.

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