Ascorbic Acid As a Modulator of Inflammatory Response Against

Overview

Journal Future Microbiol

Specialties Infectious Diseases
Microbiology

Date 2024 Apr 17

PMID 38629904

Authors

Noala Vicensoto Moreira Milhan

Aline da Graca Sampaio

Cristiane Yumi Koga-Ito

Angela Bruzzaniti

Affiliations

Soon will be listed here.

Abstract

To evaluate the behavior of oral keratinocytes in the presence of Vitamin C (Vit C) and its anti-inflammatory potential. Oral keratinocytes were initially exposed to 0.1-2.5 mM of Vit C and the metabolic activity and cell migration were evaluated using MTS assay and Ibidi culture inserts, respectively. After, the cells were challenged with and inflammatory markers were analyzed by qPCR. The treatment was not cytotoxic, and the highest concentrations increased the metabolic activity at 24 h. Vit C delayed the cell migration at 48 and 72 h. Interestingly, it downregulated the genes and . Vit C could be an interesting adjuvant to anti-fungal treatment due to its anti-inflammatory potential.

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