Functional Significance of Mirna-149 in Lung Cancer: Can It Be Utilized As a Potential Biomarker or a Therapeutic Target?

Overview

Journal Austin J Med Oncol

Publisher Austin Publishing Group

Date 2024 Apr 17

PMID 38628497

Authors

S J Chauhan

A Thyagarajan

R P Sahu

Affiliations

Soon will be listed here.

Abstract

Accumulating evidence has documented the significance of miR-149 as a promising tumor-suppressive non-coding RNA that play critical roles in regulating genes involved in cancer growth and metastasis. Notably, the ability of miR-149 to be utilized as a potential biomarker in the diagnosis/prognosis or a therapeutic target has also been explored using various cellular and preclinical models, as well as in clinical settings of lung cancer. While the applicability of miR-149 in assessing tumor progression has been suggested, its potential in predicting treatment outcomes is needed to be verified in diverse settings of lung cancer patients. The current review presents an overview of the functional significance of miR-149 with ongoing challenges in non-small cell lung cancer.

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