Assessing Cognitive Impairment in Home-dwelling Chinese Elders Aged 80+: a Detailed Survey of 13,000 Participants Focusing on Demographic Factors, Social Engagement, and Disease Prevalence

Overview

Journal Front Psychiatry

Specialty Psychiatry

Date 2024 Apr 17

PMID 38628263

Authors

Sensen Bian

Xiaobing Tian

Fanli Meng

Chunjie Xu

Yan Zhao

Qian Gao

Chengzhi Bian

Affiliations

Soon will be listed here.

Abstract

Introduction: Cognitive Impairment (CI) in the elderly, encompassing conditions ranging from Mild Cognitive Impairment (MCI) to dementia, represents a growing public health concern globally. This study aims to investigate the prevalence and correlates of CI among individuals aged 80 and above.

Methods: The study conducts 13,027 elderly individual's door-to-door surveys, followed by the cross-tabulation of analysis data, logistic regression analysis, and health condition assessments to examine various determinants of CI.

Results: The current study's key findings demonstrate sub-statical correlations between CI and various factors, including educational attainment, marital status, and gender. Pronounced differences are evident between urban and rural demographics. Furthermore, aspects of social engagement, notably communication proficiency and sensory capabilities, exhibit a strong association with CI. Logistic regression analysis highlights that residing in rural areas (Odds Ratio [OR] = 0.637) and being female (OR = 0.71) are linked to a decreased risk of CI. In contrast, behavioral and health-related variables present a complex picture. Specifically, aggressive behavior (Adjusted OR = 1.881) and symptoms of depression (Adjusted OR = 0.549) contrast with conditions such as asthma (OR= 2.857) and cerebral infarction (OR=1.348), which elevate the risk of CI. Intriguingly, hyperlipidemia (OR= 0.671) appears to confer a protective effect against CI.

Conclusion: The study highlights the complexity of factors affecting CI in the elderly, advocating for a comprehensive approach to understanding and managing cognitive health.

References

Han R, Tang Z, Ma L . Related factors of cognitive impairment in community-dwelling older adults in Beijing Longitudinal Study of Aging. Aging Clin Exp Res. 2018; 31(1):95-100. DOI: 10.1007/s40520-018-0943-8. View

Deng Y, Zhao S, Cheng G, Yang J, Li B, Xu K . The Prevalence of Mild Cognitive Impairment among Chinese People: A Meta-Analysis. Neuroepidemiology. 2021; 55(2):79-91. DOI: 10.1159/000512597. View

Demurtas J, Schoene D, Torbahn G, Marengoni A, Grande G, Zou L . Physical Activity and Exercise in Mild Cognitive Impairment and Dementia: An Umbrella Review of Intervention and Observational Studies. J Am Med Dir Assoc. 2020; 21(10):1415-1422.e6. DOI: 10.1016/j.jamda.2020.08.031. View

Chan C, Fage B, K Burton J, Smailagic N, Gill S, Herrmann N . Mini-Cog for the diagnosis of Alzheimer's disease dementia and other dementias within a secondary care setting. Cochrane Database Syst Rev. 2019; 9:CD011414. PMC: 6744952. DOI: 10.1002/14651858.CD011414.pub2. View

Solfrizzi V, Panza F, Colacicco A, DIntrono A, Capurso C, Torres F . Vascular risk factors, incidence of MCI, and rates of progression to dementia. Neurology. 2004; 63(10):1882-91. DOI: 10.1212/01.wnl.0000144281.38555.e3. View

Dennison E, Laskou F, Westbury L, Bevilacqua G, Fuggle N, Iidaka T . Do lifestyle, anthropometric and demographic factors associated with muscle strength differ in a UK and Japanese cohort? An exploratory analysis. Aging Clin Exp Res. 2023; 35(12):3097-3104. PMC: 10721682. DOI: 10.1007/s40520-023-02614-5. View

Margari F, Sicolo M, Spinelli L, Mastroianni F, Pastore A, Craig F . Aggressive behavior, cognitive impairment, and depressive symptoms in elderly subjects. Neuropsychiatr Dis Treat. 2012; 8:347-53. PMC: 3415308. DOI: 10.2147/NDT.S33745. View

Rost N, Meschia J, Gottesman R, Wruck L, Helmer K, Greenberg S . Cognitive Impairment and Dementia After Stroke: Design and Rationale for the DISCOVERY Study. Stroke. 2021; 52(8):e499-e516. PMC: 8316324. DOI: 10.1161/STROKEAHA.120.031611. View

Saczynski J, Sigurdsson S, Jonsdottir M, Eiriksdottir G, Jonsson P, Garcia M . Cerebral infarcts and cognitive performance: importance of location and number of infarcts. Stroke. 2009; 40(3):677-82. PMC: 3244834. DOI: 10.1161/STROKEAHA.108.530212. View

10.

Qu Y, Zhuo L, Li N, Hu Y, Chen W, Zhou Y . Prevalence of post-stroke cognitive impairment in china: a community-based, cross-sectional study. PLoS One. 2015; 10(4):e0122864. PMC: 4395303. DOI: 10.1371/journal.pone.0122864. View

11.

Lam R, Kennedy S, Mclntyre R, Khullar A . Cognitive dysfunction in major depressive disorder: effects on psychosocial functioning and implications for treatment. Can J Psychiatry. 2015; 59(12):649-54. PMC: 4304584. DOI: 10.1177/070674371405901206. View

12.

Gao Q, Zang E, Bi J, Dubrow R, R Lowe S, Chen H . Long-term ozone exposure and cognitive impairment among Chinese older adults: A cohort study. Environ Int. 2022; 160:107072. PMC: 8821373. DOI: 10.1016/j.envint.2021.107072. View

13.

Doi T, Verghese J, Shimada H, Makizako H, Tsutsumimoto K, Hotta R . Motoric Cognitive Risk Syndrome: Prevalence and Risk Factors in Japanese Seniors. J Am Med Dir Assoc. 2015; 16(12):1103.e21-5. DOI: 10.1016/j.jamda.2015.09.003. View

14.

Shami A, Brennan M, St Marie P, Lindenauer P, Stefan M . The association of cognitive impairment as screened by the Mini-Cog with long term post-hospitalization outcomes. Arch Gerontol Geriatr. 2019; 85:103916. PMC: 6818962. DOI: 10.1016/j.archger.2019.103916. View

15.

Morley J . An Overview of Cognitive Impairment. Clin Geriatr Med. 2018; 34(4):505-513. DOI: 10.1016/j.cger.2018.06.003. View

16.

Tiwary N, Treggiari M, Yanez N, Kirsch J, Tekkali P, Taylor C . Agreement Between the Mini-Cog in the Preoperative Clinic and on the Day of Surgery and Association With Postanesthesia Care Unit Delirium: A Cohort Study of Cognitive Screening in Older Adults. Anesth Analg. 2020; 132(4):1112-1119. DOI: 10.1213/ANE.0000000000005197. View

17.

Ding D, Zhao Q, Guo Q, Liang X, Luo J, Yu L . Progression and predictors of mild cognitive impairment in Chinese elderly: A prospective follow-up in the Shanghai Aging Study. Alzheimers Dement (Amst). 2016; 4:28-36. PMC: 4950613. DOI: 10.1016/j.dadm.2016.03.004. View

18.

Gottesman R, Albert M, Alonso A, Coker L, Coresh J, Davis S . Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort. JAMA Neurol. 2017; 74(10):1246-1254. PMC: 5710244. DOI: 10.1001/jamaneurol.2017.1658. View

19.

Donaghy P, Barnett N, Olsen K, Taylor J, McKeith I, OBrien J . Symptoms associated with Lewy body disease in mild cognitive impairment. Int J Geriatr Psychiatry. 2017; 32(11):1163-1171. DOI: 10.1002/gps.4742. View

20.

Richards K, Shue V, Beck C, Lambert C, Bliwise D . Restless legs syndrome risk factors, behaviors, and diagnoses in persons with early to moderate dementia and sleep disturbance. Behav Sleep Med. 2010; 8(1):48-61. PMC: 3745281. DOI: 10.1080/15402000903425769. View