Regulatory Effect of Osteocytes on Extramedullary and Bone Marrow Adipose Tissue Development and Function

Overview

Journal Curr Osteoporos Rep

Publisher Current Science

Specialties Endocrinology
Orthopedics

Date 2024 Apr 16

PMID 38625510

Authors

Beata Lecka-Czernik

Mohd Parvez Khan

Joshua Letson

Sudipta Baroi

Amit Chougule

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: This review summarizes evidence on osteocyte support of extramedullary and bone marrow adipocyte development and discusses the role of endogenous osteocyte activities of nuclear receptors peroxisome proliferator-activated receptor gamma (PPARG) and alpha (PPARA) in this support.

Recent Findings: PPARG and PPARA proteins, key regulators of glucose and fatty acid metabolism, are highly expressed in osteocytes. They play significant roles in the regulation of osteocyte secretome and osteocyte bioenergetics; both activities contributing to the levels of systemic energy metabolism in part through an effect on metabolic function of extramedullary and bone marrow adipocytes. The PPARs-controlled osteocyte endocrine/paracrine activities, including sclerostin expression, directly regulate adipocyte function, while the PPARs-controlled osteocyte fuel utilization and oxidative phosphorylation contribute to the skeletal demands for glucose and fatty acids, whose availability is under the control of adipocytes. Bone is an inherent element of systemic energy metabolism with PPAR nuclear receptors regulating osteocyte-adipocyte metabolic axes.

Citing Articles

The Analysis of ECE1 and PPARG Variants in the Development of Osteopenia and Osteoporosis in Postmenopausal Women.

Uzar I, Bogacz A, Luszczynska M, Wolek M, Kotrych K, Modrzejewski A Biomedicines. 2024; 12(7).

PMID: 39062013 PMC: 11274254. DOI: 10.3390/biomedicines12071440.

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