Type and Location of Adenomyosis in Women with Recurrent Pregnancy Loss: A Transvaginal Ultrasonographic Assessment

Overview

Journal Reprod Sci

Publisher Springer

Specialty Reproductive Medicine

Date 2024 Apr 15

PMID 38619796

Authors

Caterina Exacoustos

Carlo Ticconi

Irene Colombi

Giuseppe Gabriele Iorio

Elena Vaquero

Aikaterini Selntigia

Barbara Chiaramonte

Giorgia Soreca

Giuseppe Rizzo

Affiliations

Soon will be listed here.

Abstract

The current knowledge on adenomyosis as a risk factor for RPL is very scant. Overall 120 women were included in this retrospective observational study. They were divided in three groups each of which consisted of 40 subjects: Group 1: women with RPL who were diagnosed to have adenomyosis on transvaginal ultrasound (TVS); Group 2: patients with RPL without ultrasonographic findings of adenomyosis; Group 3: patients with ultrasound diagnosis of adenomyosis without RPL and at least one live birth pregnancy. The copresence of endometriosis was also investigated. Among women with RPL, patients with adenomyosis (Group 1) had higher number of pregnancy losses (p = 0.03) and lower age at first pregnancy loss (p = 0.03) than women without adenomyosis (Group 2). Moreover, they had more frequently primary RPL (p = 0.008). Adenomyosis of the inner myometrium was found more frequently (p = 0.04) in patients of Group 1 than in patients of Group 3 in which adenomyosis was mainly in the outer myometrium (p= 0.02). No differences were found in the severity of adenomyosis between these two groups of women. TVS findings for endometriosis were observed more frequently in women with adenomyosis without RPL (Group 3) than in the other two groups of patients. Adenomyosis can be a factor involved in RPL. Differences in adenomyosis localization are associated with different risks for RPL. Patients with RPL should be investigated for the presence of adenomyosis and also for the type and localization of the disease in the different myometrial layers.

Citing Articles

Adenomyosis: An Update Concerning Diagnosis, Treatment, and Fertility.

Selntigia A, Molinaro P, Tartaglia S, Pellicer A, Galliano D, Cozzolino M J Clin Med. 2024; 13(17).

PMID: 39274438 PMC: 11396652. DOI: 10.3390/jcm13175224.

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