Comparative Study of Postmortem MRI and Pathological Findings in Malignant Brain Tumors

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 Apr 15

PMID 38618299

Authors

Norihiko Saito

Nozomi Hirai

Yuki Koyahara

Sho Sato

Yu Hiramoto

Satoshi Fujita

Haruo Nakayama

Morito Hayashi

Keisuke Ito

Satoshi Iwabuchi

Affiliations

Soon will be listed here.

Abstract

This study compared magnetic resonance imaging (MRI) findings of postmortem brain specimens with neuropathological findings to evaluate the value of postmortem MRI. Postmortem MRI was performed on five formalin-fixed whole brains with malignant tumors. Postmortem T2-weighted images detected all neuropathological abnormalities as high-signal regions but also showed histological tumor invasion in areas without edema. Tumor lesions with high necrosis and edema showed high signal intensity on T2-weighted images; in three cases, lesion enlargement was detected on the final prenatal imaging and postmortem MRI. Disease progression immediately before death may have contributed to this difference. In conclusion, the correlation between MRI and neuropathological findings facilitates understanding of the mechanisms responsible for MRI abnormalities. Increased free water due to edema, necrosis, and brain tissue injury can explain the increased signal intensity observed on T2-weighted images. Postmortem MRI may contribute to effective pathology by identifying subtle abnormalities prior to brain dissection.

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