Antioxidant and Anti-inflammatory Applications of Aqueous-Root Extract-Mediated Synthesis of ZnO Nanoparticles

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2024 Apr 15

PMID 38617686

Authors

Kaneez Fatima

Mohammad Asif

Umar Farooq

Sadaf Jamal Gilani

May Nasser Bin Jumah

Mohammed Muqtader Ahmed

Affiliations

Soon will be listed here.

Abstract

In the present study, ZnO nanoparticles were synthesized by using aqueous extracts of roots. Characterization of as-prepared ZnO nanoparticles was carried out using different techniques, including powder X-ray diffraction (XRD), UV-vis diffuse reflectance spectroscopy (DRS), Fourier transform infrared (FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and BET surface area analysis. Morphological analysis confirmed the small, aggregated flake-shaped morphology of as-synthesized ZnO nanostructures. The as-prepared ZnO nanoparticles were analyzed for their potential application as anti-inflammatory (using in vivo inhibition of carrageenan induced paw edema) and antioxidant (using in vitro radical scavenging activity) agents. The ZnO nanoparticles were found to have a potent antioxidant and anti-inflammatory activity comparable to that of standard ascorbic acid (antioxidant) and indomethacin (anti-inflammatory drug). Therefore, due to their ecofriendly synthesis, nontoxicity, and biocompatible nature, zinc oxide nanoparticles synthesized successfully from roots extract of the plant with potent efficiencies can be utilized for different biomedical applications.

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