Detection of Clade 2.3.4.4b Highly Pathogenic H5N1 Influenza Virus in New York City

Overview

Journal bioRxiv

Date 2024 Apr 15

PMID 38617218

Authors

Philip S Meade

Pooja Bandawane

Kaitlyn Bushfield

Irene Hoxie

Karla R Azcona

Daneidy Burgos

Sadia Choudhury

Adama Diaby

Mariama Diallo

Kailani Gaynor

Aaron Huang

Kadiatou Kante

Shehryar N Khan

William Kim

Paul Kehinde Ajayi

Ericka Roubidoux

Sasha Nelson

Rita McMahon

Randy A Albrecht

Florian Krammer

Christine Marizzi

Affiliations

Soon will be listed here.

Abstract

Highly pathogenic avian influenza viruses of the H5N1 clade 2.3.4.4b arrived in North America in the winter of 2021/2022. These viruses have spread across the Americas causing morbidity and mortality in both wild and domestic birds as well as some mammalian species, including cattle. Many surveillance programs in wildlife as well as commercial poultry operations have detected these viruses. Here we conducted surveillance of avian species in the urban environment in New York City. We detected highly pathogenic H5N1 viruses in six samples from four different bird species and performed full genome sequencing. Sequence analysis showed the presence of multiple different genotypes. Our work highlights that the interface between animals and humans that may give rise to zoonotic infections or even pandemics is not limited to rural environments and commercial poultry operations but extends into the heart of our urban centers.

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