The Mechanism of USP43 in the Development of Tumor: a Literature Review

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2024 Apr 13

PMID 38613804

Authors

Ziqi Zhao

Meichen Liu

Zhikun Lin

Mengru Zhu

Linlin Lv

Xinqing Zhu

Rui Fan

Abdullah Al-Danakh

Hui He

Guang Tan

Affiliations

Soon will be listed here.

Abstract

Ubiquitination of the proteins is crucial for governing protein degradation and regulating fundamental cellular processes. Deubiquitinases (DUBs) have emerged as significant regulators of multiple pathways associated with cancer and other diseases, owing to their capacity to remove ubiquitin from target substrates and modulate signaling. Consequently, they represent potential therapeutic targets for cancer and other life-threatening conditions. USP43 belongs to the DUBs family involved in cancer development and progression. This review aims to provide a comprehensive overview of the existing scientific evidence implicating USP43 in cancer development. Additionally, it will investigate potential small-molecule inhibitors that target DUBs that may have the capability to function as anti-cancer medicines.

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