Age and Aging Process Alter the Gut Microbes

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2024 Apr 13

PMID 38613799

Authors

Qu Zhanbo

Zhuang Jing

Han Shugao

Wu Yinhang

Chu Jian

Yu Xiang

Zhao Feimin

Liu Jian

Wu Xinyue

Wu Wei

Han Shuwen

Affiliations

Soon will be listed here.

Abstract

Background: Gut microbes and age are both factors that influence the development of disease. The community structure of gut microbes is affected by age.

Objective: To plot time-dependent gut microbe profiles in individuals over 45 years old and explore the correlation between age and gut microbes.

Methods: Fecal samples were collected from 510 healthy individuals over 45 years old. Shannon index, Simpson index, Ace index, etc. were used to analyze the diversity of gut microbes. The beta diversity analysis, including non-metric multidimensional scaling (NMDS), was used to analyze community distribution. Linear discriminant analysis (LDA) and random forest (RF) algorithm were used to analyze the differences of gut microbes. Trend analysis was used to plot the abundances of characteristic gut microbes in different ages.

Results: The individuals aged 45-49 had the highest richness of gut bacteria. Fifteen characteristic gut microbes, including and , were screened by RF algorithm. The abundance of and were higher in individuals older than 65 years. Moreover, the abundance of , and decreased with age and the abundance of and a increased with age. The functional genes, such as human diseases and aging, were significantly different among different aged individuals.

Conclusions: The individuals in different ages have characteristic gut microbes. The changes in community structure of gut microbes may be related to age-induced diseases.

Citing Articles

Abnormalities in gut virome signatures linked with cognitive impairment in older adults.

James A, Adil N, Goltz D, Tangudu D, Chaudhari D, Shukla R Gut Microbes. 2024; 16(1):2431648.

PMID: 39676708 PMC: 11651276. DOI: 10.1080/19490976.2024.2431648.

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