Glycated Serum Protein is Independently Associated with Progressive Infarction in Patients with Acute Ischemic Stroke

Overview

Journal J Int Med Res

Publisher Sage Publications

Specialty General Medicine

Date 2024 Apr 13

PMID 38613248

Authors

Keji Zou

Caixia Wei

Qin Huang

Zubing Xu

Xiaocheng Mao

Hudie Zhang

Chenying Zeng

Lanjiao Zhang

Jing Lin

Yuling Yi

Jinchong Zhang

Affiliations

Soon will be listed here.

Abstract

Objective: This study investigated the relationship between glycated serum protein (GSP) and progressive infarction (PI).

Methods: From April 2017 to December 2020, we recruited 477 patients within 48 hours after the onset of acute ischemic stroke into this case-control study. Demographic characteristics, clinical information, and laboratory and neuroimaging data were recorded after admission.

Results: PI occurred in 144 (30.8%) patients. Patients with PI had higher initial National Institute of Health Stroke Scale (NIHSS) scores, higher discharge NIHSS scores, higher modified Rankin scale scores at 3 months after onset, higher GSP levels, lower prothrombin times, and lower creatinine levels than patients without PI. The likelihood of PI increased with increases in the GSP quartile. Multiple regression analysis revealed that high GSP levels (>2.14 mmol/L) were independently associated with PI. Subgroup analyses identified high GSP levels as an independent predictor of PI in patients with large artery atherosclerosis (third quartile: odds ratio [OR] = 3.793; 95% confidence interval [CI] = 1.555-9.250; fourth quartile: OR = 2.675; 95% CI = 1.056-6.776) and anterior circulation small vessel occlusion (fourth quartile: OR = 13.859; 95% CI = 2.024-94.885).

Conclusions: GSP might be an independent predictor for PI in certain patients with acute ischemic stroke.

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