Autoimmune Liver Diseases and Rheumatoid Arthritis-Is There an Etiopathogenic Link?

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Apr 13

PMID 38612658

Authors

Ioana Ruxandra Mihai

Ciprian Rezus

Maria Alexandra Burlui

Anca Cardoneanu

Luana Andreea Macovei

Patricia Richter

Ioana Bratoiu

Elena Rezus

Affiliations

Soon will be listed here.

Abstract

Rheumatoid arthritis (RA) is a systemic immune-mediated disease that, in addition to the articular involvement, can have extra-articular manifestations. Even though liver damage in RA is not very common, associated autoimmune liver diseases (AILDs) may occur. The most common AILD associated with RA is primary biliary cirrhosis (PBC), followed by autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC). There are common underlying mechanisms that play a role in the emergence of autoimmunity and inflammation in both rheumatic and autoimmune liver diseases. Genetic studies have revealed the existence of several common disease-associated genes shared between RA and AILDs, and infectious triggers, particularly those associated with recurrent or complicated urinary tract infections, are also speculated to be potential triggers for these conditions. Moreover, these diseases share common serologic patterns characterized by the presence of specific autoantibodies and hyper-gammaglobulinemia. In this study, we focus on reviewing the association between RA and AILDs regarding the prevalence and possible etiopathogenic link.

Citing Articles

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Zhang J, Hu Y, Xu J, Shao H, Zhu Q, Si H Front Microbiol. 2024; 15:1442506.

PMID: 39736991 PMC: 11684339. DOI: 10.3389/fmicb.2024.1442506.

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