The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Apr 13

PMID 38612394

Authors

Kamil Krauz

Marcel Kempinski

Pawel Janczak

Karol Momot

Maciej Zarebinski

Izabela Poprawa

Malgorzata Wojciechowska

Affiliations

Soon will be listed here.

Abstract

Epicardial adipose tissue (EAT) is a fat deposit surrounding the heart and located under the visceral layer of the pericardium. Due to its unique features, the contribution of EAT to the pathogenesis of cardiovascular and metabolic disorders is extensively studied. Especially, EAT can be associated with the onset and development of coronary artery disease, myocardial infarction and post-infarct heart failure which all are significant problems for public health. In this article, we focus on the mechanisms of how EAT impacts acute coronary syndromes. Particular emphasis was placed on the role of inflammation and adipokines secreted by EAT. Moreover, we present how EAT affects the remodeling of the heart following myocardial infarction. We further review the role of EAT as a source of stem cells for cardiac regeneration. In addition, we describe the imaging assessment of EAT, its prognostic value, and its correlation with the clinical characteristics of patients.

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References

Tanindi A, Erkan A, Ekici B . Epicardial adipose tissue thickness can be used to predict major adverse cardiac events. Coron Artery Dis. 2015; 26(8):686-91. DOI: 10.1097/MCA.0000000000000296. View

Uygur B, Celik O, Demir A, Karakayali M, Arslan C, Temur H . Epicardial adipose tissue volume predicts long term major adverse cardiovascular events in patients with Type 2 diabetes. Turk Kardiyol Dern Ars. 2021; 49(2):127-134. DOI: 10.5543/tkda.2021.65635. View

Wang Z, Zhang J, Zhang A, Sun Y, Su M, You H . The role of epicardial and pericoronary adipose tissue radiomics in identifying patients with non-ST-segment elevation myocardial infarction from unstable angina. Heliyon. 2023; 9(5):e15738. PMC: 10160514. DOI: 10.1016/j.heliyon.2023.e15738. View

Berbee J, Boon M, Khedoe P, Bartelt A, Schlein C, Worthmann A . Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun. 2015; 6:6356. PMC: 4366535. DOI: 10.1038/ncomms7356. View

Zeisberg E, Ma Q, Juraszek A, Moses K, Schwartz R, Izumo S . Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest. 2005; 115(6):1522-31. PMC: 1090473. DOI: 10.1172/JCI23769. View

Sacks H, Fain J, Bahouth S, Ojha S, Frontini A, Budge H . Adult epicardial fat exhibits beige features. J Clin Endocrinol Metab. 2013; 98(9):E1448-55. DOI: 10.1210/jc.2013-1265. View

Akoumianakis I, Antoniades C . The interplay between adipose tissue and the cardiovascular system: is fat always bad?. Cardiovasc Res. 2017; 113(9):999-1008. DOI: 10.1093/cvr/cvx111. View

Comert N, Yucel O, Ege M, Yaylak B, Erdogan G, Yilmaz M . Echocardiographic epicardial adipose tissue predicts subclinical atherosclerosis: epicardial adipose tissue and atherosclerosis. Angiology. 2012; 63(8):586-90. DOI: 10.1177/0003319711432452. View

Zencirci E, Zencirci A, Degirmencioglu A, Karakus G, Ugurlucan M, Ozden K . The relationship between epicardial adipose tissue and ST-segment resolution in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Heart Vessels. 2014; 30(2):147-53. DOI: 10.1007/s00380-013-0459-2. View

10.

Fadini G, Mehta A, Dhindsa D, Bonora B, Sreejit G, Nagareddy P . Circulating stem cells and cardiovascular outcomes: from basic science to the clinic. Eur Heart J. 2020; 41(44):4271-4282. PMC: 7825095. DOI: 10.1093/eurheartj/ehz923. View

11.

Hendricks S, Dykun I, Balcer B, Totzeck M, Rassaf T, Mahabadi A . Epicardial adipose tissue is a robust measure of increased risk of myocardial infarction - a meta-analysis on over 6600 patients and rationale for the EPIC-ACS study. Medicine (Baltimore). 2021; 100(52):e28060. PMC: 8718235. DOI: 10.1097/MD.0000000000028060. View

12.

Nalliah C, Bell J, Raaijmakers A, Waddell H, Wells S, Bernasochi G . Epicardial Adipose Tissue Accumulation Confers Atrial Conduction Abnormality. J Am Coll Cardiol. 2020; 76(10):1197-1211. DOI: 10.1016/j.jacc.2020.07.017. View

13.

Mazurek T, Kochman J, Kobylecka M, Wilimski R, Filipiak K, Krolicki L . Inflammatory activity of pericoronary adipose tissue may affect plaque composition in patients with acute coronary syndrome without persistent ST-segment elevation: preliminary results. Kardiol Pol. 2013; 72(5):410-6. DOI: 10.5603/KP.a2013.0320. View

14.

Muthalaly R, Nerlekar N, Wong D, Cameron J, Seneviratne S, Ko B . Epicardial adipose tissue and myocardial ischemia assessed by computed tomography perfusion imaging and invasive fractional flow reserve. J Cardiovasc Comput Tomogr. 2017; 11(1):46-53. DOI: 10.1016/j.jcct.2016.12.007. View

15.

Shan T, Shuwen Z, Hengbin W, Min Z . Can EAT be an INOCA goalkeeper. Front Endocrinol (Lausanne). 2023; 13:1028429. PMC: 9895377. DOI: 10.3389/fendo.2022.1028429. View

16.

Dubey L, Zeng H, Wang H, Liu R . Potential role of adipocytokine leptin in acute coronary syndrome. Asian Cardiovasc Thorac Ann. 2008; 16(2):124-8. DOI: 10.1177/021849230801600209. View

17.

Parisi V, Petraglia L, DEsposito V, Cabaro S, Rengo G, Caruso A . Statin therapy modulates thickness and inflammatory profile of human epicardial adipose tissue. Int J Cardiol. 2018; 274:326-330. DOI: 10.1016/j.ijcard.2018.06.106. View

18.

Bando S, Fukuda D, Soeki T, Nishimoto S, Uematsu E, Matsuura T . Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis. Atherosclerosis. 2015; 242(2):407-14. DOI: 10.1016/j.atherosclerosis.2015.07.043. View

19.

Romijn M, Danad I, Bakkum M, Stuijfzand W, Tulevski I, Somsen G . Incremental diagnostic value of epicardial adipose tissue for the detection of functionally relevant coronary artery disease. Atherosclerosis. 2015; 242(1):161-6. DOI: 10.1016/j.atherosclerosis.2015.07.005. View

20.

Sen F, Yilmaz S, Balci K, Gul M, Balci M, Akboga M . The Relationship Between Epicardial Adipose Tissue Thickness and Infarct-Related Artery Patency in Patients With ST-Segment Elevation Myocardial Infarction. Angiology. 2015; 67(3):281-6. DOI: 10.1177/0003319715591330. View