Factors Impacting Microwave Ablation Zone Sizes: A Retrospective Analysis

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2024 Apr 13

PMID 38610957

Authors

Rene Michael Mathy

Athanasios Giannakis

Mareike Franke

Alain Winiger

Hans-Ulrich Kauczor

De-Hua Chang

Affiliations

Soon will be listed here.

Abstract

Purpose: Evaluation of the influence of intrinsic and extrinsic conditions on ablation zone volumes (AZV) after microwave ablation (MWA).

Methods: Retrospective analysis of 38 MWAs of therapy-naïve liver tumours performed with the NeuWave PR probe. Ablations were performed either in the 'standard mode' (65 W, 10 min) or in the 'surgical mode' (95 W, 1 min, then 65 W, 10 min). AZV measurements were obtained from contrast-enhanced computed tomography immediately post-ablation.

Results: AZVs in the 'standard mode' were smaller than predicted by the manufacturer (length 3.6 ± 0.6 cm, 23% below 4.7 cm; width 2.7 ± 0.6, 23% below 3.5 cm). Ablation zone past the tip was limited to 6 mm in 28/32 ablations. Differences in AZV between the 'surgical mode' and 'standard mode' were not significant (15.6 ± 7.8 mL vs. 13.9 ± 8.8 mL, = 0.6). AZVs were significantly larger in case of hepatocellular carcinomas (HCCs) ( = 19) compared to metastasis ( = 19; 17.8 ± 9.9 mL vs. 10.1 ± 5.1 mL, = 0.01) and in non-perivascular tumour location ( = 14) compared to perivascular location ( = 24, 18.7 ± 10.4 mL vs. 11.7 ± 6.1 mL, = 0.012), with both factors remaining significant in two-way analysis of variance (HCC vs. metastasis: = 0.02; perivascular vs. non-perivascular tumour location: = 0.044).

Conclusion: Larger AZVs can be expected in cases of HCCs compared with metastases and in non-perivascular locations. Using the 'surgical mode' does not increase AZV significantly.

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