Macrolide Resistance Detection is Needed in University Settings

remains a difficult sexually-transmitted infection (STI) to manage due to its potential for antimicrobial resistance and post-infection sequelae. University students are especially vulnerable, as this demographic has the highest rate of STI in the United States. As a result, investigating prevalence rates and therapeutic outcomes in this population is essential to minimize future impact of The purpose of this study was to investigate a university student population for distribution and treatment outcome. Retrospective chart-review of university health clinic attendees, augmented by laboratory detection of following therapeutic intervention. A total of 1617 student encounters at a midwestern United States university health clinic over a 28-month interval from November 2017 through February 2020 were analyzed for and positivity rates and prevalence. Detection of these sexually-transmitted pathogens occurred by commercial RNA amplification testing. Chart review was focused on participant outcomes following initial detection and therapeutic intervention. positivity and prevalence rates were 7.05% and 9.00%, respectively, while analogous rates for were 7.05% and 6.51%, respectively. An average of 1.83 positive results was generated from participants infected with at any time, with an average of 1.17 positive results for ( < 0.0002). For students treated with azithromycin, 30.3% generated a negative result upon follow-up, with 1g daily and 2-day 500mg dosing regimens demonstrating less efficacy than a 4-day 250mg regimen or moxifloxacin. Data indicate a need for molecular macrolide resistance determination from primary specimens in the university setting.