Licensing Effects of Inflammatory Factors and TLR Ligands on the Regenerative Capacity of Adipose-derived Mesenchymal Stem Cells

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2024 Apr 12

PMID 38606318

Authors

Diana Szucs

Tamas Monostori

Vanda Miklos

Zoltan G Pahi

Szilard Poliska

Lajos Kemeny

Zoltan Vereb

Affiliations

Soon will be listed here.

Abstract

Adipose tissue-derived mesenchymal stem cells are promising contributors to regenerative medicine, exhibiting the ability to regenerate tissues and modulate the immune system, which is particularly beneficial for addressing chronic inflammatory ulcers and wounds. Despite their inherent capabilities, research suggests that pretreatment amplifies therapeutic effectiveness. Our experimental design exposed adipose-derived mesenchymal stem cells to six inflammatory factors for 24 h. We subsequently evaluated gene expression and proteome profile alterations and observed the wound closure rate post-treatment. Specific pretreatments, such as IL-1β, notably demonstrated an accelerated wound-healing process. Analysis of gene and protein expression profiles revealed alterations in pathways associated with tissue regeneration. This suggests that licensed cells exhibit potentially higher therapeutic efficiency than untreated cells, shedding light on optimizing regenerative strategies using adipose tissue-derived stem cells.

Citing Articles

Chemoresistance in Pancreatic Cancer: The Role of Adipose-Derived Mesenchymal Stem Cells and Key Resistance Genes.

Parvaneh S, Miklos V, Pahi Z, Szucs D, Monostori T, Poliska S Int J Mol Sci. 2025; 26(1.

PMID: 39796244 PMC: 11720846. DOI: 10.3390/ijms26010390.

Increased DNA damage of adipose tissue-derived mesenchymal stem cells under inflammatory conditions.

Pahi Z, Szucs D, Miklos V, Ordog N, Monostori T, Varga J Heliyon. 2024; 10(17):e36275.

PMID: 39296022 PMC: 11407982. DOI: 10.1016/j.heliyon.2024.e36275.

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