ACE2 and TMPRSS2 Expression in Patients Before, During, and After SARS-CoV-2 Infection

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2024 Apr 12

PMID 38606293

Authors

Henrique Borges da Silva Grisard

Marcos Andre Schorner

Fernando Hartmann Barazzetti

Julia Kinetz Wachter

Manoela Valmorbida

Glauber Wagner

Gislaine Fongaro

Maria Luiza Bazzo

Affiliations

Soon will be listed here.

Abstract

During the SARS-CoV-2 pandemic angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) were constantly under the scientific spotlight, but most studies evaluated ACE2 and TMPRSS2 expression levels in patients infected by SARS-CoV-2. Thus, this study aimed to evaluate the expression levels of both proteins before, during, and after-infection. For that, nasopharyngeal samples from 26 patients were used to measure ACE2/TMPRSS2 ex-pression via qPCR. Symptomatic patients presented lower ACE2 expression levels before and after the infection than those in asymptomatic patients; however, these levels increased during SARS-CoV-2 infection. In addition, symptomatic patients presented higher expression levels of TMPRSS2 pre-infection, which decreased in the following periods. In summary, ACE2 and TMPRSS2 expression levels are potential risk factors for the development of symptomatic COVID-19, and the presence of SARS-CoV-2 potentially modulates those levels.

Citing Articles

SARS-CoV-2 Genomic Variants and Their Relationship with the Expressional and Genomic Profile of Angiotensin-Converting Enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2).

da Silva Grisard H, Schorner M, Barazzetti F, Wachter J, Benetti Filho V, Martinez R Microorganisms. 2024; 12(11).

PMID: 39597701 PMC: 11596641. DOI: 10.3390/microorganisms12112312.

Mapping ACE2 and TMPRSS2 co-expression in human brain tissue: implications for SARS-CoV-2 neurological manifestations.

Gupta T, Kumar M, Kaur U, Rao A, Bharti R J Neurovirol. 2024; 30(3):316-326.

PMID: 38600308 DOI: 10.1007/s13365-024-01206-x.

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