The Role of Cellular Polyploidy in the Regeneration of the Cirrhotic Liver in Rats and Humans

Overview

Journal Comp Cytogenet

Date 2024 Apr 11

PMID 38601956

Authors

Natalia N Bezborodkina

Vsevolod Ya Brodsky

Boris N Kudryavtsev

Affiliations

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Abstract

Polyploidy is a condition in which a cell has multiple diploid sets of chromosomes. Two forms of polyploidy are known. One of them, generative polyploidy, is characteristic of all cells of the organism, while the other form develops only in some somatic tissues at certain stages of postnatal ontogenesis. Whole genome duplication has played a particularly important role in the evolution of plants and animals, while the role of cellular (somatic) polyploidy in organisms remains largely unclear. In this work we investigated the contribution of cellular polyploidy to the normal and the reparative liver growth of (Berkenhout, 1769) and Linnaeus, 1758. It is shown that polyploidy makes a significant contribution to the increase of the liver mass both in the course of normal postnatal development and during pathological process.

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﻿The Role of Cellular Polyploidy in the Regeneration of the Cirrhotic Liver in Rats and Humans

The Role of Cellular Polyploidy in the Regeneration of the Cirrhotic Liver in Rats and Humans