A Review on Ferroptosis and Photodynamic Therapy Synergism: Enhancing Anticancer Treatment

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Apr 11

PMID 38601678

Authors

Qihang Chang

Peiru Wang

Qingyu Zeng

Xiuli Wang

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is an iron-dependent programmed cell death modality, which has showed great potential in anticancer treatment. Photodynamic therapy (PDT) is widely used in clinic as an anticancer therapy. PDT combined with ferroptosis-promoting therapy has been found to be a promising strategy to improve anti-cancer therapy efficacy. Fenton reaction in ferroptosis can provide oxygen for PDT, and PDT can produce reactive oxygen species for Fenton reaction to enhance ferroptosis. In this review, we briefly present the importance of ferroptosis in anticancer treatment, mechanism of ferroptosis, researches on PDT induced ferroptosis, and the mechanism of the synergistic effect of PDT and ferroptosis on cancer killing.

Citing Articles

Photodynamic Therapy Using IR-783 Liposomes for Advanced Tongue and Breast Cancers in Humans.

Komura Y, Kimura S, Hirasawa Y, Katagiri T, Takaura A, Yoshida F J Funct Biomater. 2024; 15(12).

PMID: 39728163 PMC: 11678438. DOI: 10.3390/jfb15120363.

Porphyrin-engineered nanoscale metal-organic frameworks: enhancing photodynamic therapy and ferroptosis in oncology.

Zou Y, Chen J, Luo X, Qu Y, Zhou M, Xia R Front Pharmacol. 2024; 15:1481168.

PMID: 39512824 PMC: 11541831. DOI: 10.3389/fphar.2024.1481168.

References

Turubanova V, Balalaeva I, Mishchenko T, Catanzaro E, Alzeibak R, Peskova N . Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine. J Immunother Cancer. 2019; 7(1):350. PMC: 6916435. DOI: 10.1186/s40425-019-0826-3. View

Zhu T, Shi L, Yu C, Dong Y, Qiu F, Shen L . Ferroptosis Promotes Photodynamic Therapy: Supramolecular Photosensitizer-Inducer Nanodrug for Enhanced Cancer Treatment. Theranostics. 2019; 9(11):3293-3307. PMC: 6567978. DOI: 10.7150/thno.32867. View

Li J, Li J, Pu Y, Li S, Gao W, He B . PDT-Enhanced Ferroptosis by a Polymer Nanoparticle with pH-Activated Singlet Oxygen Generation and Superb Biocompatibility for Cancer Therapy. Biomacromolecules. 2021; 22(3):1167-1176. DOI: 10.1021/acs.biomac.0c01679. View

Fang L, Han M, Zhang Y, Song Y, Liu B, Cai M . Single Component Organic Photosensitizer with NIR-I Emission Realizing Type-I Photodynamic and GSH-Depletion Caused Ferroptosis Synergistic Theranostics. Adv Healthc Mater. 2023; 12(21):e2300134. DOI: 10.1002/adhm.202300134. View

Wang X, Wu M, Zhang X, Li F, Zeng Y, Lin X . Hypoxia-responsive nanoreactors based on self-enhanced photodynamic sensitization and triggered ferroptosis for cancer synergistic therapy. J Nanobiotechnology. 2021; 19(1):204. PMC: 8265128. DOI: 10.1186/s12951-021-00952-y. View

Yang W, Stockwell B . Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. 2008; 15(3):234-45. PMC: 2683762. DOI: 10.1016/j.chembiol.2008.02.010. View

Yang S, Wu Y, Zhong W, Chen R, Wang M, Chen M . GSH/pH Dual Activatable Cross-linked and Fluorinated PEI for Cancer Gene Therapy Through Endogenous Iron De-Hijacking and in Situ ROS Amplification. Adv Mater. 2023; 36(2):e2304098. DOI: 10.1002/adma.202304098. View

Shui S, Zhao Z, Wang H, Conrad M, Liu G . Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway. Redox Biol. 2021; 45:102056. PMC: 8264218. DOI: 10.1016/j.redox.2021.102056. View

Li X, Lovell J, Yoon J, Chen X . Clinical development and potential of photothermal and photodynamic therapies for cancer. Nat Rev Clin Oncol. 2020; 17(11):657-674. DOI: 10.1038/s41571-020-0410-2. View

10.

Dixon S, Lemberg K, Lamprecht M, Skouta R, Zaitsev E, Gleason C . Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012; 149(5):1060-72. PMC: 3367386. DOI: 10.1016/j.cell.2012.03.042. View

11.

Shishido Y, Amisaki M, Matsumi Y, Yakura H, Nakayama Y, Miyauchi W . Antitumor Effect of 5-Aminolevulinic Acid Through Ferroptosis in Esophageal Squamous Cell Carcinoma. Ann Surg Oncol. 2020; 28(7):3996-4006. DOI: 10.1245/s10434-020-09334-4. View

12.

Alvarez N, Sevilla A . Current Advances in Photodynamic Therapy (PDT) and the Future Potential of PDT-Combinatorial Cancer Therapies. Int J Mol Sci. 2024; 25(2). PMC: 10815790. DOI: 10.3390/ijms25021023. View

13.

Wang X, Chen Y, Yang X, Cheng L, He Z, Xin Y . Activation of ALOX12 by a multi-organelle-orienting photosensitizer drives ACSL4-independent cell ferroptosis. Cell Death Dis. 2022; 13(12):1040. PMC: 9751149. DOI: 10.1038/s41419-022-05462-9. View

14.

Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P . BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol. 2018; 20(10):1181-1192. PMC: 6170713. DOI: 10.1038/s41556-018-0178-0. View

15.

Guo X, Yu H, Shen W, Cai R, Li Y, Li G . Synthesis and biological evaluation of NO-donor containing photosensitizers to induce ferroptosis of cancer cells. Bioorg Chem. 2021; 116:105355. DOI: 10.1016/j.bioorg.2021.105355. View

16.

Chen J, Duan Z, Deng L, Li L, Li Q, Qu J . Cell Membrane-Targeting Type I/II Photodynamic Therapy Combination with FSP1 Inhibition for Ferroptosis-Enhanced Photodynamic Immunotherapy. Adv Healthc Mater. 2024; 13(16):e2304436. DOI: 10.1002/adhm.202304436. View

17.

Doll S, Porto Freitas F, Shah R, Aldrovandi M, Costa Da Silva M, Ingold I . FSP1 is a glutathione-independent ferroptosis suppressor. Nature. 2019; 575(7784):693-698. DOI: 10.1038/s41586-019-1707-0. View

18.

cunderlikova B, Kluckova K, Babal P, Mlkvy P, Teplicky T . Modifications of DAMPs levels in extracellular environment induced by aminolevulinic acid-based photodynamic therapy of esophageal cancer cells. Int J Radiat Biol. 2024; 100(5):802-816. DOI: 10.1080/09553002.2024.2310002. View

19.

Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X . Ferroptosis is an autophagic cell death process. Cell Res. 2016; 26(9):1021-32. PMC: 5034113. DOI: 10.1038/cr.2016.95. View

20.

Zhou Y, Zhang Y, Jiang C, Chen Y, Tong F, Yang X . Rosmarinic Acid-Crosslinked Supramolecular Nanoassembly with Self-Regulated Photodynamic and Anti-Metastasis Properties for Synergistic Photoimmunotherapy. Small. 2023; 19(23):e2300594. DOI: 10.1002/smll.202300594. View