Cardiovascular Disease and Cancer: Shared Risk Factors and Mechanisms

Overview

Journal Nat Rev Cardiol

Specialty Cardiology & Vascular Diseases

Date 2024 Apr 10

PMID 38600368

Authors

Nicholas S Wilcox

Uri Amit

Jacob B Reibel

Eva Berlin

Kendyl Howell

Bonnie Ky

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease (CVD) and cancer are among the leading causes of morbidity and mortality globally, and these conditions are increasingly recognized to be fundamentally interconnected. In this Review, we present the current epidemiological data for each of the modifiable risk factors shared by the two diseases, including hypertension, hyperlipidaemia, diabetes mellitus, obesity, smoking, diet, physical activity and the social determinants of health. We then review the epidemiological data demonstrating the increased risk of CVD in patients with cancer, as well as the increased risk of cancer in patients with CVD. We also discuss the shared mechanisms implicated in the development of these conditions, highlighting their inherent bidirectional relationship. We conclude with a perspective on future research directions for the field of cardio-oncology to advance the care of patients with CVD and cancer.

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