CHARMM GUI Membrane Builder for Oxidized Phospholipid Membrane Modeling and Simulation

Overview

Journal Curr Opin Struct Biol

Date 2024 Apr 10

PMID 38598982

Authors

Turner P Brown

Dane E Santa

Brett A Berger

Lingyang Kong

Nathan J Wittenberg

Wonpil Im

Affiliations

Soon will be listed here.

Abstract

Oxidative stress leads to the production of oxidized phospholipids (oxPLs) that modulate the biophysical properties of phospholipid monolayers and bilayers. As many immune cells are responsible for surveilling cells and tissues for the presence of oxPLs, oxPL-dependent mechanisms have been suggested as targets for treating chronic kidney disease, atherosclerosis, diabetes, and cancer metastasis. This review details recent experimental and computational studies that characterize oxPLs' behaviors in various monolayers and bilayers. These studies investigate how the tail length and polar functional groups of OxPLs impact membrane properties, how oxidized membranes can be stabilized, and how membrane integrity is generally affected by oxidized lipids. In addition, for oxPL-containing membrane modeling and simulation, CHARMM-GUI Membrane Builder has been extended to support a variety of oxPLs, accelerating the simulation system building process for these biologically relevant lipid bilayers.

Citing Articles

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