Gastric Cancer: A Comprehensive Literature Review

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 Apr 10

PMID 38595903

Authors

Reda H Mithany

M Hasaan Shahid

Mina Manasseh

Muhammad Talha Saeed

Samana Aslam

Mohamed S Mohamed

Nesma Daniel

Affiliations

Soon will be listed here.

Abstract

Gastric cancer stands as a significant global health concern, particularly prevalent in Eastern Asia, with high mortality rates urging urgent attention and research efforts. This article comprehensively explores the epidemiology, anatomy, risk factors, pathophysiology, clinical presentation, diagnosis, staging, treatment modalities, prevention strategies, and survival rates associated with gastric cancer. Notably, infection, dietary choices, and intricate stomach anatomy play pivotal roles in disease development. Early detection, utilizing staging, grading, and genetic testing for personalized treatment approaches is emphasized. Treatment modalities encompass surgery, chemotherapy, radiation therapy, targeted therapy, and immunotherapy. Prevention strategies involve lifestyle changes, screening, and genetic counseling. Survival rates vary by stage, highlighting the need for individualized care. In conclusion, a collaborative global effort is essential to address the impact of gastric cancer and improve outcomes.

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References

Hui Y, Tu C, Liu D, Zhang H, Gong X . Risk factors for gastric cancer: A comprehensive analysis of observational studies. Front Public Health. 2023; 10:892468. PMC: 9845896. DOI: 10.3389/fpubh.2022.892468. View

Chong I, Chau I . Is there still a place for radiotherapy in gastric cancer?. Curr Opin Pharmacol. 2023; 68:102325. DOI: 10.1016/j.coph.2022.102325. View

Fong C, Johnston E, Starling N . Neoadjuvant and Adjuvant Therapy Approaches to Gastric Cancer. Curr Treat Options Oncol. 2022; 23(9):1247-1268. DOI: 10.1007/s11864-022-01004-9. View

Lee K, Van Cutsem E, Bang Y, Fuchs C, Kudaba I, Garrido M . Association of Tumor Mutational Burden with Efficacy of Pembrolizumab±Chemotherapy as First-Line Therapy for Gastric Cancer in the Phase III KEYNOTE-062 Study. Clin Cancer Res. 2022; 28(16):3489-3498. DOI: 10.1158/1078-0432.CCR-22-0121. View

Giubelan A, Stancu M, Hontaru S, Malaescu G, Badea-Voiculescu O, Firoiu C . Tumor angiogenesis in gastric cancer. Rom J Morphol Embryol. 2023; 64(3):311-318. PMC: 10720935. DOI: 10.47162/RJME.64.3.03. View

Santoro R, Ettorre G, Santoro E . Subtotal gastrectomy for gastric cancer. World J Gastroenterol. 2014; 20(38):13667-80. PMC: 4194551. DOI: 10.3748/wjg.v20.i38.13667. View

Wee P, Wang Z . Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways. Cancers (Basel). 2017; 9(5). PMC: 5447962. DOI: 10.3390/cancers9050052. View

Zhou J, Zheng R, Zhang S, Chen R, Wang S, Sun K . Gastric and esophageal cancer in China 2000 to 2030: Recent trends and short-term predictions of the future burden. Cancer Med. 2022; 11(8):1902-1912. PMC: 9041080. DOI: 10.1002/cam4.4586. View

Jomrich G, Schoppmann S . Targeted therapy in gastric cancer. Eur Surg. 2016; 48(5):278-284. PMC: 5065582. DOI: 10.1007/s10353-016-0389-1. View

10.

Padda J, Khalid K, Cooper A, Jean-Charles G . Association Between Helicobacter pylori and Gastric Carcinoma. Cureus. 2021; 13(5):e15165. PMC: 8216031. DOI: 10.7759/cureus.15165. View

11.

Park J, von Karsa L, Herrero R . Prevention strategies for gastric cancer: a global perspective. Clin Endosc. 2014; 47(6):478-89. PMC: 4260094. DOI: 10.5946/ce.2014.47.6.478. View

12.

Humphrys E, Walter F, Rubin G, Emery J, Johnson M, Richards A . Patient symptom experience prior to a diagnosis of oesophageal or gastric cancer: a multi-methods study. BJGP Open. 2020; 4(1). PMC: 7330188. DOI: 10.3399/bjgpopen20X101001. View

13.

Singh S, Bhat M, Sathe G, Gopal C, Sharma J, Madugundu A . Proteomic Signatures of Diffuse and Intestinal Subtypes of Gastric Cancer. Cancers (Basel). 2021; 13(23). PMC: 8656738. DOI: 10.3390/cancers13235930. View

14.

Zhu Z, Gong Y, Xu H . Clinical and pathological staging of gastric cancer: Current perspectives and implications. Eur J Surg Oncol. 2020; 46(10 Pt B):e14-e19. DOI: 10.1016/j.ejso.2020.06.006. View

15.

Malone E, Oliva M, Sabatini P, Stockley T, Siu L . Molecular profiling for precision cancer therapies. Genome Med. 2020; 12(1):8. PMC: 6961404. DOI: 10.1186/s13073-019-0703-1. View

16.

Carneiro F . Familial and hereditary gastric cancer, an overview. Best Pract Res Clin Gastroenterol. 2022; 58-59:101800. DOI: 10.1016/j.bpg.2022.101800. View

17.

Weledji E . The principles of the surgical management of gastric cancer. Int J Surg Oncol (N Y). 2017; 2(7):e11. PMC: 5673153. DOI: 10.1097/IJ9.0000000000000011. View

18.

Eusebi L, Telese A, Marasco G, Bazzoli F, Zagari R . Gastric cancer prevention strategies: A global perspective. J Gastroenterol Hepatol. 2020; 35(9):1495-1502. DOI: 10.1111/jgh.15037. View

19.

Giandola T, Maino C, Marrapodi G, Ratti M, Ragusi M, Bigiogera V . Imaging in Gastric Cancer: Current Practice and Future Perspectives. Diagnostics (Basel). 2023; 13(7). PMC: 10093088. DOI: 10.3390/diagnostics13071276. View

20.

Yang L, Ying X, Liu S, Lyu G, Xu Z, Zhang X . Gastric cancer: Epidemiology, risk factors and prevention strategies. Chin J Cancer Res. 2021; 32(6):695-704. PMC: 7797232. DOI: 10.21147/j.issn.1000-9604.2020.06.03. View