The Role of Vasculature and Angiogenesis in Respiratory Diseases

Overview

Journal Angiogenesis

Publisher Springer

Specialty Hematology

Date 2024 Apr 5

PMID 38580869

Authors

Maximilian Ackermann

Christopher Werlein

Edith Plucinski

Sophie Leypold

Mark P Kuhnel

Stijn E Verleden

Hassan A Khalil

Florian Langer

Tobias Welte

Steven J Mentzer

Danny D Jonigk

Affiliations

Soon will be listed here.

Abstract

In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-threatening diseases such as COPD, pulmonary hypertension, IPF or lung cancer. The contribution of blood vessels and angiogenesis to lung regeneration, remodeling and disease progression has been increasingly appreciated. The vascular supply of the lung shows the peculiarity of dual perfusion of the pulmonary circulation (vasa publica), which maintains a functional blood-gas barrier, and the bronchial circulation (vasa privata), which reveals a profiled capacity for angiogenesis (namely intussusceptive and sprouting angiogenesis) and alveolar-vascular remodeling by the recruitment of endothelial precursor cells. The aim of this review is to outline the importance of vascular remodeling and angiogenesis in a variety of non-neoplastic and neoplastic acute and chronic respiratory diseases such as lung infection, COPD, lung fibrosis, pulmonary hypertension and lung cancer.

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