O-linked β-N-acetylglucosaminylation May Be a Key Regulatory Factor in Promoting Osteogenic Differentiation of Bone Marrow Mesenchymal Stromal Cells

Overview

Journal World J Stem Cells

Publisher Baishideng Publishing Group

Date 2024 Apr 5

PMID 38577231

Authors

Xu-Chang Zhou

Guo-Xin Ni

Affiliations

Soon will be listed here.

Abstract

Cumulative evidence suggests that O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) plays an important regulatory role in pathophysiological processes. Although the regulatory mechanisms of O-GlcNAcylation in tumors have been gradually elucidated, the potential mechanisms of O-GlcNAcylation in bone metabolism, particularly, in the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) remains unexplored. In this study, the literature related to O-GlcNAcylation and BMSC osteogenic differentiation was reviewed, assuming that it could trigger more scholars to focus on research related to O-GlcNAcylation and bone metabolism and provide insights into the development of novel therapeutic targets for bone metabolism disorders such as osteoporosis.

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