The Roles of Non-coding RNAs in Hirschsprung's Disease

Overview

Journal Noncoding RNA Res

Date 2024 Apr 5

PMID 38577013

Authors

Yang Yang

Xinwei Hou

Chen Wang

Qinming Chen

Yi Lu

Daiyue Yu

Kai Wu

Affiliations

Soon will be listed here.

Abstract

Hirschsprung's disease (HSCR) is a congenital disorder characterized by the absence of ganglion cells in the colon, leading to various intestinal complications. The etiology of HSCR stems from complex genetic and environmental interactions, of which the intricate roles of non-coding RNAs (ncRNAs) are a key area of research. However, the roles of ncRNAs in the pathogenesis of HSCR have not been fully elucidated. In order to understand the variety of symptoms caused by HSCR and develop new therapeutic approaches, it is essential to understand the underlying biological genetic basis of HSCR. This review presents a comprehensive overview of the current understanding regarding the involvement of ncRNAs in HSCR, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). Additionally, it provides a summary of the molecular mechanisms through which ncRNAs regulate the expression of genes related to the proliferation, migration, and differentiation of intestinal neural crest cells, thereby contributing to the advancement of HSCR research.

Citing Articles

Causes and consequences: development and pathophysiology of Hirschsprung disease.

Burns A, Goldstein A World J Pediatr Surg. 2024; 7(4):e000903.

PMID: 39600627 PMC: 11590806. DOI: 10.1136/wjps-2024-000903.

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