The Role of Hydrogels in the Management of Brain Tumours: a Narrative Review

Overview

Journal Ann Med Surg (Lond)

Publisher Wolters Kluwer

Specialty Medical Education

Date 2024 Apr 5

PMID 38576913

Authors

Zahra Anas

Syeda Fatima Saba Hasan

Muhammad Abdul Moiz

Muhammad Abdul Wasay Zuberi

Hussain Haider Shah

Aima Ejaz

Tirth Dave

Muhammad Hasnain Panjwani

Sameer Abdul Rauf

Muhammad Sheheryar Hussain

Radeyah Waseem

Affiliations

Soon will be listed here.

Abstract

Conventional therapeutic techniques for brain tumours have limitations and side effects, necessitating the need for alternative treatment options. MRI-monitored therapeutic hydrogel systems show potential as a non-surgical approach for brain tumour treatment. Hydrogels have unique physical and chemical properties that make them promising for brain tumour treatment, including the ability to encapsulate therapeutic agents, provide sustained and controlled drug release, and overcome the blood-brain barrier for better penetration. By combining hydrogel systems with MRI techniques, it is possible to develop therapeutic approaches that provide real-time monitoring and controlled release of therapeutic agents. Surgical resection remains important, but there is a growing need for alternative approaches that can complement or replace traditional methods. The objective of this comprehensive narrative review is to evaluate the potential of MRI-monitored therapeutic hydrogel systems in non-surgical brain tumour treatment.

References

Chen C, Jing W, Chen Y, Wang G, Abdalla M, Gao L . Intracavity generation of glioma stem cell-specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy. Sci Transl Med. 2022; 14(656):eabn1128. DOI: 10.1126/scitranslmed.abn1128. View

Tsui C, Koss K, Churchward M, Todd K . Biomaterials and glia: Progress on designs to modulate neuroinflammation. Acta Biomater. 2018; 83:13-28. DOI: 10.1016/j.actbio.2018.11.008. View

Burkett C, Patel S, Tabor M, Padhya T, Vale F . Polyethylene glycol (PEG) hydrogel dural sealant and collagen dural graft matrix in transsphenoidal pituitary surgery for prevention of postoperative cerebrospinal fluid leaks. J Clin Neurosci. 2011; 18(11):1513-7. DOI: 10.1016/j.jocn.2011.04.005. View

Jogalekar M, Cooper L, Serrano E . Hydrogel Environment Supports Cell Culture Expansion of a Grade IV Astrocytoma. Neurochem Res. 2017; 42(9):2610-2624. PMC: 6217807. DOI: 10.1007/s11064-017-2308-7. View

Dzhonova D, Olariu R, Leckenby J, Dhayani A, Vemula P, Prost J . Local release of tacrolimus from hydrogel-based drug delivery system is controlled by inflammatory enzymes in vivo and can be monitored non-invasively using in vivo imaging. PLoS One. 2018; 13(8):e0203409. PMC: 6117083. DOI: 10.1371/journal.pone.0203409. View

Yang Z, Huang R, Zheng B, Guo W, Li C, He W . Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing. Adv Sci (Weinh). 2021; 8(8):2003627. PMC: 8061386. DOI: 10.1002/advs.202003627. View

Vashist A, Vashist A, Gupta Y, Ahmad S . Recent advances in hydrogel based drug delivery systems for the human body. J Mater Chem B. 2020; 2(2):147-166. DOI: 10.1039/c3tb21016b. View

Erthal L, Gobbo O, Ruiz-Hernandez E . Biocompatible copolymer formulations to treat glioblastoma multiforme. Acta Biomater. 2020; 121:89-102. DOI: 10.1016/j.actbio.2020.11.030. View

Shi W, Fang F, Kong Y, Greer S, Kuss M, Liu B . Dynamic hyaluronic acid hydrogel with covalent linked gelatin as an anti-oxidative bioink for cartilage tissue engineering. Biofabrication. 2021; 14(1). DOI: 10.1088/1758-5090/ac42de. View

10.

Hartmann M, Heiland S, Sartor K . [Functional MRI procedures in the diagnosis of brain tumors: Perfusion- and diffusion-weighted imaging]. Rofo. 2002; 174(8):955-64. DOI: 10.1055/s-2002-32918. View

11.

McCrorie P, Mistry J, Taresco V, Lovato T, Fay M, Ward I . Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours. Eur J Pharm Biopharm. 2020; 157:108-120. DOI: 10.1016/j.ejpb.2020.10.005. View

12.

Tang-Schomer M, Chandok H, Wu W, Lau C, Bookland M, George J . 3D patient-derived tumor models to recapitulate pediatric brain tumors In Vitro. Transl Oncol. 2022; 20:101407. PMC: 8980497. DOI: 10.1016/j.tranon.2022.101407. View

13.

Bashir S, Hina M, Iqbal J, Rajpar A, Mujtaba M, Alghamdi N . Fundamental Concepts of Hydrogels: Synthesis, Properties, and Their Applications. Polymers (Basel). 2020; 12(11). PMC: 7697203. DOI: 10.3390/polym12112702. View

14.

Bastiancich C, Vanvarenberg K, Ucakar B, Pitorre M, Bastiat G, Lagarce F . Lauroyl-gemcitabine-loaded lipid nanocapsule hydrogel for the treatment of glioblastoma. J Control Release. 2016; 225:283-93. DOI: 10.1016/j.jconrel.2016.01.054. View

15.

Thakor J, Ahadian S, Niakan A, Banton E, Nasrollahi F, Hasani-Sadrabadi M . Engineered Hydrogels for Brain Tumor Culture and Therapy. Biodes Manuf. 2020; 3(3):203-226. PMC: 7402618. DOI: 10.1007/s42242-020-00084-6. View

16.

Berger T, Wen P, Lang-Orsini M, Chukwueke U . World Health Organization 2021 Classification of Central Nervous System Tumors and Implications for Therapy for Adult-Type Gliomas: A Review. JAMA Oncol. 2022; 8(10):1493-1501. DOI: 10.1001/jamaoncol.2022.2844. View

17.

Han H, Jeong J, Kim J, Seung W . Postoperative Thecal Sac Compression Induced by Hydrogel Dural Sealant after Spinal Schwannoma Removal. Korean J Neurotrauma. 2020; 16(1):99-104. PMC: 7192801. DOI: 10.13004/kjnt.2020.16.e10. View

18.

Gadelha M, Chieffo C, Bai S, Hu X, Frohman L . A subcutaneous octreotide hydrogel implant for the treatment of acromegaly. Endocr Pract. 2012; 18(6):870-81. DOI: 10.4158/EP11388.OR. View

19.

Perkins A, Liu G . Primary Brain Tumors in Adults: Diagnosis and Treatment. Am Fam Physician. 2016; 93(3):211-7. View

20.

Liu J, Wang K, Luan J, Wen Z, Wang L, Liu Z . Visualization of in situ hydrogels by MRI in vivo. J Mater Chem B. 2020; 4(7):1343-1353. DOI: 10.1039/c5tb02459e. View