and Are Potential Biomarkers Associated with Immune Infiltration in Heart Failure and Pan-cancer

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Apr 5

PMID 38576566

Authors

Jian Wang

Lin Cai

Gang Huang

Chunbin Wang

Zhen Zhang

Junbo Xu

Affiliations

Soon will be listed here.

Abstract

Heart failure (HF) and cancer are the two leading causes of death worldwide and affect one another in a bidirectional way. We aimed to identify hub therapeutic genes as potential biomarkers for the identification and treatment of HF and cancer. Gene expression data of heart samples from patients with ischemic HF (IHF) and healthy controls were retrieved from the GSE42955 and GSE57338 databases. Difference analysis and weighted gene co-expression network analysis (WGCNA) were used to identify key modules associated with IHF. The overlapping genes were subjected to gene and protein enrichment analyses to construct a protein-protein interaction (PPI) network, which was screened for hub genes among the overlapping genes. A total of eight hub genes were subjected to correlation, immune cell infiltration, and ROC analyses. Then we analyzed the roles of two significant genes in 33 tumor types to explore their potential as common targets in HF and cancer. A total of 85 genes were identified by WGCNA and differentially expressed gene (DEG) analyses. and were identified as the hub genes with IHF. Finally, and were identified as potential common targets for IHF and cancer. These findings provide new perspectives for expanding our understanding of the etiology and underlying mechanisms of HF and cancer.

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