Novel Bioactive Extract from Yarrow Obtained by the Supercritical Antisolvent-assisted Technique Inhibits Lipid Metabolism in Colorectal Cancer

Overview

Journal Front Bioeng Biotechnol

Date 2024 Apr 5

PMID 38576446

Authors

Marta Gomez de Cedron

Maria de Las Nieves Siles-Sanchez

Diego Martin-Hernandez

Laura Jaime

Susana Santoyo

Ana Ramirez de Molina

Affiliations

Soon will be listed here.

Abstract

Altered lipid metabolism in cancer is associated to dissemination and prognosis. Bioactive compounds naturally occurring in L. (yarrow) have been reported to exert antitumour activities. Food biotechnology may provide on-demand mixtures of bioactive compounds with complementary activities in cancer treatment. Supercritical-antisolvent-precipitation (SAS) has been applied to fractionate the bioactive compounds from an Ultrasound-Assisted-Extraction yarrow extract resulting in two extracts with distinct polarity, yarrow-precipitate-(PP) and yarrow-separator-(Sep). Total phenolic content and relevant essential oils have been characterized. Antioxidant, anti-inflammatory and antiproliferative activities have been compared. Moreover, the effect on the inhibition of colorectal cancer cells' bioenergetics has been evaluated. Yarrow-PP exerted the highest antioxidant activity, even higher than the complete UAE-yarrow extract, meanwhile yarrow-Sep showed the highest anti-inflammatory activity, even higher than the complete UAE-yarrow extract. Interestingly, yarrow-Sep inhibited key lipid metabolic targets in CRC cells extensively shown to be implicated in cancer dissemination and prognosis -, , and - and epithelial to mesenchymal targets-, , and -augmenting cell adhesion. In summary, SAS technology has been applied to provide a novel combination of bioactive compounds, yarrow-Sep, which merits further research to be proposed as a potential complementary nutraceutical in the treatment of CRC.

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