Cardiac Resident Macrophages: Spatiotemporal Distribution, Development, Physiological Functions, and Their Translational Potential on Cardiac Diseases

Overview

Journal Acta Pharm Sin B

Publisher Elsevier

Specialty Pharmacology

Date 2024 Apr 4

PMID 38572111

Authors

Jing Jin

Yurou Wang

Yueqin Liu

Subrata Chakrabarti

Zhaoliang Su

Affiliations

Soon will be listed here.

Abstract

Cardiac resident macrophages (CRMs) are the main population of cardiac immune cells. The role of these cells in regeneration, functional remodeling, and repair after cardiac injury is always the focus of research. However, in recent years, their dynamic changes and contributions in physiological states have a significant attention. CRMs have specific phenotypes and functions in different cardiac chambers or locations of the heart and at different stages. They further show specific differentiation and development processes. The present review will summarize the new progress about the spatiotemporal distribution, potential developmental regulation, and their roles in cardiac development and aging as well as the translational potential of CRMs on cardiac diseases. Of course, the research tools for CRMs, their respective advantages and disadvantages, and key issues on CRMs will further be discussed.

Citing Articles

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References

Lichanska A, Hume D . Origins and functions of phagocytes in the embryo. Exp Hematol. 2000; 28(6):601-11. DOI: 10.1016/s0301-472x(00)00157-0. View

Nicolas-Avila J, Lechuga-Vieco A, Esteban-Martinez L, Sanchez-Diaz M, Diaz-Garcia E, Santiago D . A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart. Cell. 2020; 183(1):94-109.e23. DOI: 10.1016/j.cell.2020.08.031. View

Wang Z, Koenig A, Lavine K, Apte R . Macrophage Plasticity and Function in the Eye and Heart. Trends Immunol. 2019; 40(9):825-841. PMC: 6719788. DOI: 10.1016/j.it.2019.07.002. View

Lo C . Role of gap junctions in cardiac conduction and development: insights from the connexin knockout mice. Circ Res. 2000; 87(5):346-8. DOI: 10.1161/01.res.87.5.346. View

Van Hove H, Martens L, Scheyltjens I, De Vlaminck K, Pombo Antunes A, De Prijck S . A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment. Nat Neurosci. 2019; 22(6):1021-1035. DOI: 10.1038/s41593-019-0393-4. View

Fan C, Chen H, Liu K, Wang Z . Fibrinogen-like protein 2 contributes to normal murine cardiomyocyte maturation and heart development. Exp Physiol. 2021; 106(7):1559-1571. DOI: 10.1113/EP089450. View

Watson S, Scigliano M, Bardi I, Ascione R, Terracciano C, Perbellini F . Preparation of viable adult ventricular myocardial slices from large and small mammals. Nat Protoc. 2017; 12(12):2623-2639. DOI: 10.1038/nprot.2017.139. View

Revelo X, Parthiban P, Chen C, Barrow F, Fredrickson G, Wang H . Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis. Circ Res. 2021; 129(12):1086-1101. PMC: 8638822. DOI: 10.1161/CIRCRESAHA.121.319737. View

Stadtfeld M, Ye M, Graf T . Identification of interventricular septum precursor cells in the mouse embryo. Dev Biol. 2006; 302(1):195-207. DOI: 10.1016/j.ydbio.2006.09.025. View

10.

Mass E . The stunning clodronate. J Exp Med. 2023; 220(6). PMC: 10067525. DOI: 10.1084/jem.20230339. View

11.

Yousefzadeh M, Flores R, Zhu Y, Schmiechen Z, Brooks R, Trussoni C . An aged immune system drives senescence and ageing of solid organs. Nature. 2021; 594(7861):100-105. PMC: 8684299. DOI: 10.1038/s41586-021-03547-7. View

12.

Gentek R, Molawi K, Sieweke M . Tissue macrophage identity and self-renewal. Immunol Rev. 2014; 262(1):56-73. DOI: 10.1111/imr.12224. View

13.

Galvan-Pena S, ONeill L . Metabolic reprograming in macrophage polarization. Front Immunol. 2014; 5:420. PMC: 4151090. DOI: 10.3389/fimmu.2014.00420. View

14.

Cahill T, Sun X, Ravaud C, Villa Del Campo C, Klaourakis K, Lupu I . Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart. Development. 2021; 148(3). PMC: 7875498. DOI: 10.1242/dev.194563. View

15.

Sun Z, Zhou D, Xie X, Wang S, Wang Z, Zhao W . Cross-talk between macrophages and atrial myocytes in atrial fibrillation. Basic Res Cardiol. 2016; 111(6):63. PMC: 5033992. DOI: 10.1007/s00395-016-0584-z. View

16.

Waleczek F, Sansonetti M, Xiao K, Jung M, Mitzka S, Dendorfer A . Chemical and mechanical activation of resident cardiac macrophages in the living myocardial slice ex vivo model. Basic Res Cardiol. 2022; 117(1):63. PMC: 9712328. DOI: 10.1007/s00395-022-00971-2. View

17.

Dick S, Wong A, Hamidzada H, Nejat S, Nechanitzky R, Vohra S . Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles. Sci Immunol. 2022; 7(67):eabf7777. DOI: 10.1126/sciimmunol.abf7777. View

18.

Hulsmans M, Clauss S, Xiao L, Aguirre A, King K, Hanley A . Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017; 169(3):510-522.e20. PMC: 5474950. DOI: 10.1016/j.cell.2017.03.050. View

19.

Nicolas-Avila J, Hidalgo A, Ballesteros I . Specialized functions of resident macrophages in brain and heart. J Leukoc Biol. 2018; 104(4):743-756. DOI: 10.1002/JLB.6MR0118-041R. View

20.

Dong Y, Zhang S, Gao X, Yin D, Wang T, Li Z . HIF1α epigenetically repressed macrophages via CRISPR/Cas9-EZH2 system for enhanced cancer immunotherapy. Bioact Mater. 2021; 6(9):2870-2880. PMC: 7905236. DOI: 10.1016/j.bioactmat.2021.02.008. View