Red Wine Contains a Potent Inhibitor of Phenolsulphotransferase

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1985 Feb 1

PMID 3857069

Citations 7

Authors

J T Littlewood

V Glover

M Sandler

Affiliations

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Abstract

Many ethanolic drinks, especially red wine, contain potent inhibitors of phenolsulphotransferase. At a dilution of 1/75 from the original beverage, extracts from six types of red wine inhibited human platelet phenolsulphotransferase P by a mean of 99% and human platelet phenolsulphotransferase M by 12%. Such extracts had no significant effect on rat liver monoamine oxidase A or human platelet monoamine oxidase B. The inhibitors, which have not yet been identified, can be extracted into ethyl acetate at acid or neutral pH. Thus, they are not monoamines. Flavonoid phenols are plausible candidates. As phenolsulphotransferase M and P are involved in the metabolism of many phenols, including drugs, the inhibition of these enzymes could result in the enhancement of pharmacological potency and have important clinical consequences.

Citing Articles

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