Twenty-One Flavors of Type 1 Innate Lymphoid Cells with PD-1 (Programmed Cell Death-1 Receptor) Sprinkles

Overview

Journal Discov Immunol

Specialty Allergy & Immunology

Date 2024 Apr 3

PMID 38567059

Authors

Katie J Smith

Giuseppe Sciume

Shoba Amarnath

Affiliations

Soon will be listed here.

Abstract

Innate lymphoid cells (ILCs) are tissue-resident immune cells that have been recently implicated in initiating and driving anti-tumor responses. ILCs are classified into three main groups, namely type 1 ILCs (ILC1), type 2 ILCs, and type 3 ILCs. All three groups have been implicated in either eliciting pro or anti-tumor immune responses in different cancer subtypes with the consensus that ILCs cannot be overlooked within the field of anti-tumor immune responses. In this review, we will specifically expand on the knowledge on ILC1, their characterization, function, and plasticity in anti-cancer immune responses. Within this premise, we will discuss caveats of ILC1 characterization, and expand on the expression and function of immune checkpoint receptors within ILC1 subsets, specifically focusing on the role of programmed cell death-1 receptor in controlling specific ILC1 responses. We summarize that ILC1s are a vital component in initiating anti-tumor responses and can be boosted by checkpoint receptors.

Citing Articles

Innate Lymphoid Cells and Their Role in the Immune Response to Infections.

Fol M, Karpik W, Zablotni A, Kulesza J, Kulesza E, Godkowicz M Cells. 2024; 13(4.

PMID: 38391948 PMC: 10886880. DOI: 10.3390/cells13040335.

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