Expression Profiles and Gene Set Enrichment Analysis of the Transcriptomes from the Cancer Tissue, White Adipose Tissue and Paracancer Tissue with Colorectal Cancer

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2024 Apr 2

PMID 38563016

Authors

Xiufeng Zhang

Rui Zhu

Ye Jiao

Halizere Simayi

Jialing He

Zhong Shen

Houdong Wang

Jun He

Suzhan Zhang

Fei Yang

Affiliations

Soon will be listed here.

Abstract

Background: Colorectal cancer (CRC) is one of the most common cancers worldwide and is related to diet and obesity. Currently, crosstalk between lipid metabolism and CRC has been reported; however, the specific mechanism is not yet understood. In this study, we screened differentially expressed long non-coding RNAs (lncRNAs) and mRNAs from primary cancer, paracancer, and white adipose tissue of CRC patients. We screened and analyzed the genes differentially expressed between primary and paracancer tissue and between paracancer and white adipose tissue but not between primary and white adipose tissue. According to the results of the biological analysis, we speculated a lncRNA (MIR503HG) that may be involved in the crosstalk between CRC and lipid metabolism through exosome delivery.

Methods: We screened differentially expressed long non-coding RNAs (lncRNAs) and mRNAs from primary cancer, paracancer, and white adipose tissue of CRC patients. We screened and analyzed the genes differentially expressed between primary and paracancer tissue and between paracancer and white adipose tissue but not between primary and white adipose tissue.

Results: We speculated a lncRNA (MIR503HG) that may be involved in the crosstalk between CRC and lipid metabolism through exosome delivery.

Conclusions: In this study, the findings raise the possibility of crosstalk between lipid metabolism and CRC through the exosomal delivery of lncRNAs.

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