Microcapsules Prepared from Okra Polysaccharides Improved Intestinal Microbiota in Alzheimer's Disease Mice

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2024 Apr 2

PMID 38562470

Authors

Yao-Kun Hsiao

Bao-Hong Lee

She-Ching Wu

Affiliations

Soon will be listed here.

Abstract

Background: Okra contains a viscous substance rich in water-soluble material, including fibers, pectin, proteoglycans, gum, and polysaccharides. This study explored the use of okra polysaccharides by microorganisms and their potential to improve microbiota.

Methods: The regulation of microcapsules prepared from okra polysaccharides with or without encapsulation on intestinal microbiota was assessed through 16S metagenomic analysis and short-chain fatty acids (SCFAs) in App mice (Alzheimer's disease; AD model).

Results: We found that and were majorly regulated by microcapsules prepared from okra polysaccharides in AD mice. Similarly, microcapsules prepared from okra polysaccharides with encapsulation markedly elevated the abundance of and and increased SCFAs in AD mice.

Conclusion: Our results suggest that microcapsules prepared from okra polysaccharides with or without encapsulation may improve intestinal microbiota by elevating levels in AD mice.

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