Environmental and Genetic Predictors of Whole Blood Mercury and Selenium Concentrations in Pregnant Women in a UK Birth Cohort

Overview

Journal Environ Adv

Specialty Environmental Health

Date 2024 Apr 2

PMID 38562418

Authors

Kyle Dack

Peiyuan Huang

Caroline M Taylor

Dheeraj Rai

Sarah J Lewis

Affiliations

Soon will be listed here.

Abstract

There is evidence that tissue concentrations of mercury (Hg) and selenium (Se) are predicted by numerous dietary, sociodemographic, environmental, and genetic factors. This study aimed to estimate the relative importance of predictors of Hg and Se concentrations in blood samples taken from pregnant women. The Avon Longitudinal Study of Parents and Children (ALSPAC) in the UK measured whole blood Hg and Se concentrations in 3,972 pregnant women. We identified 30 potential predictors of Hg and 24 of Se, which were evaluated using cross-validated random forests to identify the optimal models for predictive power. The relative importance of individual variables was estimated by averaging the added-R per predictor. Linkage disequilibrium score regression was used to estimate the variance explained by genotype. A multivariable model of 14 predictors explained 22.4% of Hg variance (95% CI: 13.0 to 37.1), including 6.9% from blood Se and 3.2% from white fish consumption. There were 11 predictors which explained 15.3% of Se variance (CI: 8.9 to 25.9), including 6.4% from blood Hg, 1.3% from blood lead, and 1.3% from oily fish. Measured genetic variation explained 30% of Hg variance (CI: 8.4 to 51.5) and 37.5% of Se (CI: 10.4 to 64.5). A high proportion of Hg and Se variance could be explained from dietary, sociodemographic, metabolic, and genetic factors. Seafood consumption was less predictive of Hg than may be expected and other factors should be considered when determining risk of exposure. There was tentative evidence that genotype is a major contributor to Hg and Se variation, possibly by modifying the efficacy of internal metabolism.

References

Park K, Rimm E, Siscovick D, Spiegelman D, Morris J, Mozaffarian D . Demographic and lifestyle factors and selenium levels in men and women in the U.S. Nutr Res Pract. 2011; 5(4):357-64. PMC: 3180687. DOI: 10.4162/nrp.2011.5.4.357. View

Ni G, Moser G, Wray N, Lee S . Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood. Am J Hum Genet. 2018; 102(6):1185-1194. PMC: 5993419. DOI: 10.1016/j.ajhg.2018.03.021. View

Jain R . Synergistic impact of co-exposures to toxic metals cadmium, lead, and mercury along with perfluoroalkyl substances on the healthy kidney function. Environ Res. 2018; 169:342-347. DOI: 10.1016/j.envres.2018.11.037. View

Drasch G, Wanghofer E, Roider G, Strobach S . Correlation of mercury and selenium in the human kidney. J Trace Elem Med Biol. 1996; 10(4):251-4. DOI: 10.1016/S0946-672X(96)80043-5. View

Zhong Q, Lin R, Nong Q . Adiposity and Serum Selenium in U.S. Adults. Nutrients. 2018; 10(6). PMC: 6024359. DOI: 10.3390/nu10060727. View

Forbes L, Graham J, Berglund C, Bell R . Dietary Change during Pregnancy and Women's Reasons for Change. Nutrients. 2018; 10(8). PMC: 6115730. DOI: 10.3390/nu10081032. View

Dack K, Bustamante M, Taylor C, Llop S, Lozano M, Yousefi P . Genome-Wide Association Study of Blood Mercury in European Pregnant Women and Children. Genes (Basel). 2023; 14(12). PMC: 10742428. DOI: 10.3390/genes14122123. View

Belhadj M, Kazi Tani L, Medjati N, Harek Y, Dali Sahi M, Sun Q . Se Status Prediction by Food Intake as Compared to Circulating Biomarkers in a West Algerian Population. Nutrients. 2020; 12(12). PMC: 7760749. DOI: 10.3390/nu12123599. View

Arthur J, Nicol F, Beckett G . The role of selenium in thyroid hormone metabolism and effects of selenium deficiency on thyroid hormone and iodine metabolism. Biol Trace Elem Res. 1992; 34(3):321-5. DOI: 10.1007/BF02783686. View

10.

Rayman M . Selenium and human health. Lancet. 2012; 379(9822):1256-68. DOI: 10.1016/S0140-6736(11)61452-9. View

11.

Bastiansz A, Ewald J, Rodriguez Saldana V, Santa-Rios A, Basu N . A Systematic Review of Mercury Exposures from Skin-Lightening Products. Environ Health Perspect. 2022; 130(11):116002. PMC: 9651181. DOI: 10.1289/EHP10808. View

12.

Phan Dinh Q, Novirsa R, Jeong H, Nugraha W, Addai-Arhin S, Viet P . Mercury, cadmium, and lead in cigarettes from international markets: concentrations, distributions and absorption ability of filters. J Toxicol Sci. 2021; 46(9):401-411. DOI: 10.2131/jts.46.401. View

13.

Bates C, Thane C, Prentice A, Delves H, Gregory J . Selenium status and associated factors in a British National Diet and Nutrition Survey: young people aged 4-18 y. Eur J Clin Nutr. 2002; 56(9):873-81. DOI: 10.1038/sj.ejcn.1601405. View

14.

Brodziak-Dopierala B, Fischer A . Analysis of Mercury Content in Various Types of Tea () and Yerba Mate (). Int J Environ Res Public Health. 2022; 19(9). PMC: 9102548. DOI: 10.3390/ijerph19095491. View

15.

Golding J, Steer C, Hibbeln J, Emmett P, Lowery T, Jones R . Dietary predictors of maternal prenatal blood mercury levels in the ALSPAC birth cohort study. Environ Health Perspect. 2013; 121(10):1214-8. PMC: 3801454. DOI: 10.1289/ehp.1206115. View

16.

Branco V, Caito S, Farina M, da Rocha J, Aschner M, Carvalho C . Biomarkers of mercury toxicity: Past, present, and future trends. J Toxicol Environ Health B Crit Rev. 2017; 20(3):119-154. PMC: 6317349. DOI: 10.1080/10937404.2017.1289834. View

17.

Mahaffey K . Mercury exposure: medical and public health issues. Trans Am Clin Climatol Assoc. 2006; 116:127-53. PMC: 1473138. View

18.

Bulik-Sullivan B, Loh P, Finucane H, Ripke S, Yang J, Patterson N . LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet. 2015; 47(3):291-5. PMC: 4495769. DOI: 10.1038/ng.3211. View

19.

Park S, Lee B . Strong positive associations between seafood, vegetables, and alcohol with blood mercury and urinary arsenic levels in the Korean adult population. Arch Environ Contam Toxicol. 2012; 64(1):160-70. DOI: 10.1007/s00244-012-9808-x. View

20.

Nielsen S, Kit B, Aoki Y, Ogden C . Seafood consumption and blood mercury concentrations in adults aged ≥20 y, 2007-2010. Am J Clin Nutr. 2014; 99(5):1066-70. PMC: 10952048. DOI: 10.3945/ajcn.113.077081. View