The Genomics of Sporadic and Hereditary Colorectal Cancer

Overview

Journal Ann R Coll Surg Engl

Specialty General Surgery

Date 2024 Mar 31

PMID 38555871

Authors

I D Sadien

R J Davies

Jmd Wheeler

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. Over the past three decades, extensive efforts have sought to elucidate the genomic landscape of CRC. These studies reveal that CRC is highly heterogeneous at the molecular level, with different subtypes characterised by distinct somatic mutational profiles, epigenetic aberrations and transcriptomic signatures. This review summarises our current understanding of the genomic and epigenomic alterations implicated in CRC development and progression. Particular focus is given to how characterisation of CRC genomes is leading to more personalised approaches to diagnosis and treatment.

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