» Articles » PMID: 38554690

New Insights into the Surface Enhanced Raman Scattering (SERS) Response of Adenine Using Chemometrics

Overview
Publisher Elsevier
Specialty Molecular Biology
Date 2024 Mar 30
PMID 38554690
Authors
Affiliations
Soon will be listed here.
Abstract

The SERS response of adenine is one of the most studied, due to its outstanding exaltation. However, the spectra obtained strongly differ according to the experimental conditions and still remain not well understood. To be able to search for the presence of this molecule in complex environments, it is essential to better understand the SERS response of adenine alone. After a brief presentation of the literature on the subject, we present results suggesting that the experimental spectra would result from the overlap of different spectroscopic signatures, that may probably be due to different non-covalent interactions or different electromagnetic fields experienced by adenine molecules. An independent component analysis is reported. Our results underline the difficulty to precisely analyze the experimental data, the need to continue this research and to constitute data banks that would allow comparing the spectra obtained in different laboratories according to the experimental conditions.

Citing Articles

Exploring Surface-Enhanced Raman Spectroscopy of Pyrazine-2-Carbonitrile for Indirect Label-Free Albumin Quantification in an Endothelium Permeability Assay.

Klement W, Duijnstee D, Telle V, Staykov A, Browne W, Verpoorte E Anal Chem. 2025; 97(7):4075-4083.

PMID: 39928859 PMC: 11866285. DOI: 10.1021/acs.analchem.4c05906.