Effect of 60 Days of Head Down Tilt Bed Rest on Amplitude and Phase of Rhythms in Physiology and Sleep in Men

Overview

Journal NPJ Microgravity

Publisher Springer Nature

Date 2024 Mar 30

PMID 38553471

Authors

Maria-Angeles Bonmati-Carrion

Nayantara Santhi

Giuseppe Atzori

Jeewaka Mendis

Sylwia Kaduk

Derk-Jan Dijk

Simon N Archer

Affiliations

Soon will be listed here.

Abstract

Twenty-four-hour rhythms in physiology and behaviour are shaped by circadian clocks, environmental rhythms, and feedback of behavioural rhythms onto physiology. In space, 24 h signals such as those associated with the light-dark cycle and changes in posture, are weaker, potentially reducing the robustness of rhythms. Head down tilt (HDT) bed rest is commonly used to simulate effects of microgravity but how HDT affects rhythms in physiology has not been extensively investigated. Here we report effects of -6° HDT during a 90-day protocol on 24 h rhythmicity in 20 men. During HDT, amplitude of light, motor activity, and wrist-temperature rhythms were reduced, evening melatonin was elevated, while cortisol was not affected during HDT, but was higher in the morning during recovery when compared to last session of HDT. During recovery from HDT, time in Slow-Wave Sleep increased. EEG activity in alpha and beta frequencies increased during NREM and REM sleep. These results highlight the profound effects of head-down-tilt-bed-rest on 24 h rhythmicity.

Citing Articles

Cardiovascular adaptations and pathological changes induced by spaceflight: from cellular mechanisms to organ-level impacts.

Han H, Jia H, Wang Y, Song J Mil Med Res. 2024; 11(1):68.

PMID: 39334239 PMC: 11429428. DOI: 10.1186/s40779-024-00570-3.

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